Abstract: Objective To investigate the correlation between platelet endothelial cell adhesion molecule-1 (PECAM-1), ventricular remodeling and severe heart failure after coronary intervention in patients with acute myocardial infarction, and the prognostic value. Methods A total of 80 patients with heart failure after coronary intervention in acute myocardial infarction admitted to our hospital from May 2020 to May 2023 were selected as the research subjects. The severity of heart failure in patients was evaluated using Killip grading and grouped into a Grade Ⅰ group of 16 cases, a Grade Ⅱ group of 23 cases, a Grade Ⅲ group of 20 cases, and a Grade Ⅳ group of 21 cases. In addition, 30 healthy volunteers who came to our hospital for physical examination during the same period were selected as the control group. Compare the levels of PECAM-1 and ventricular remodeling indicators in five groups of patients, and use Spearman correlation analysis to analyze the correlation between PECAM-1, ventricular remodeling, and severe heart failure after coronary intervention in acute myocardial infarction. Subsequently, 80 patients with heart failure after coronary intervention in acute myocardial infarction were divided into a death group (n=20) and the remaining patients into a survival group (n=60). The clinical general situation of the two groups of patients was compared, and the predictive value of PECAM-1 and ventricular remodeling on the prognosis of heart failure after coronary intervention in acute myocardial infarction was analyzed. Results The PECAM-1 and LVMI levels in grade IV patients were significantly higher than those in grade III, II, I, and control groups, while LVRI levels were lower than those in grade III, II, I, and control groups (P<0.05); Spearman correlation analysis showed that PECAM-1 and LVMI were positively correlated with severe heart failure after coronary intervention in acute myocardial infarction, while LVRI was negatively correlated with severe heart failure after coronary intervention in acute myocardial infarction (P<0.05); There were significant differences in Killip grade, comorbidities with old myocardial infarction, PECAM-1, LVRI, and LVMI levels between the survival group and the death group (P<0.05); The results of logistic regression analysis showed that PECAM-1 (OR=2.458, 95%CI:1.359~3.257), LVRI (OR=2.546, 95%CI:1.364~3.475), LVMI (OR=2.774, 95%CI:1.876~4.010) were independent predictive indicators of heart failure after acute myocardial infarction intervention (P<0.05). Conclusion PECAM-1, ventricular remodeling, and severe heart failure after coronary intervention in acute myocardial infarction are significantly correlated, and can predict the prognosis of severe heart failure after coronary intervention in acute myocardial infarction through PECAM-1 and ventricular remodeling.

Key words: platelet endothelial cell adhesion molecule-1, ventricular remodeling, cute myocardial infarction, coronary intervention, heart failure