Abstract: ： Objective To explore the diagnostic and prognostic prediction of anticardiolipin antibodies (ACA), angiotensin converting enzyme (ACE), and serum zinc ion concentration in elderly patients with acute myocardial infarction and heart failure. Methods A total of 84 patients with acute myocardial infarction combined with heart failure admitted to the People's Hospital of Inner Mongolia Autonomous Region from March 2020 to March 2023 were selected and divided into the heart failure group, and 80 patients with simple acute myocardial infarction without complicated heart failure treated in the same period were selected as the non-heart failure group. By comparing ACA, ACE, and serum zinc ion concentration, the subject characteristic (ROC) working curve was established to analyze the diagnostic value of ACA, ACE and serum zinc ion on acute myocardial infarction combined with heart failure in the elderly. Subsequently, 84 patients with acute myocardial infarction and heart failure were divided into death group (n=20), and the remaining patients were divided into survival group (n=64). The clinical general situation of the two groups was compared, and the predictive value of ACA, ACE and serum zinc ion concentration on the prognosis of acute myocardial infarction with heart failure was analyzed. Results ACA and ACE were significantly higher in the heart failure group than that in the non-heart failure group, and the zinc ion concentration was significantly lower than that in the non-heart failure group (P<0.05). The diagnostic efficacy of the combination of ACA, ACE, and serum zinc ions in elderly patients with acute myocardial infarction combined with heart failure is better than that of a single test. There was no significant difference in sex, age, BMI, diabetes, hypertension, hyperlipidemia, left ventricular ejection fraction, number of stents, and length of stents between the survival group and the death group (P>0.05). There was significant difference in Killip grade, old myocardial infarction, ACA, ACE, and serum zinc concentration between the survival group and the death group (P<0.05). The results of logistic regression analysis showed that Killip grade, ACA, ACE and serum zinc ions were independent predictors of the outcome of acute myocardial infarction with heart failure. Conclusion The combination of ACA, ACE, and serum zinc ion concentration has high diagnostic value for acute myocardial infarction with heart failure, and clinical practice can consider predicting the prognosis of patients with acute myocardial infarction with heart failure through ACA, ACE, and serum zinc ion concentration.

Key words: anticardiolipin antibodies, angiotensin converting enzyme, zinc ions, acute myocardial infarction, heart failure