Abstract: Objective To explore the clinical efficacy of thiamphenicol combined with colistin transdermal patch in the treatment of tic disorders. Methods A total of 119 children with tic disorders admitted to the pediatric outpatient clinic of the Third People's Hospital of Longgang from May 2022 to May 2023 were selected as the study subjects, they were randomly divided into three groups. The combined group of 41 cases were treated with thiamphenicol combined with colistin transdermal patch. The thiamphenicol group of 39 cases were treated with oral thiamphenicol hydrochloride tablets. The colistin group of 39 cases were treated with a single colistin transdermal patch. Ttreatment of the three groups lasted 8 weeks. The Yale Grade Tourette Syndrome Score (YGTSS), treatment efficiency, and dangerous events were recorded through the whole study. Results The YGTSS scores of children in the three groups were lower at 8 w and 12 w after treatment compared with those before treatment, and the YGTSS scores of the combined group were lower compared with those of the other two single-administration groups (P<0.05), and the differences in YGTSS scores of the single thiabendazole group compared with those of the single colestipol group were not statistically significant at 8w and 12w after treatment (P>0.05). The total effective rate of the three groups were 87.8% in the combined group, 82.05% in the tiapride group and 84.62% in the clonidine group (P>0.05). The incidence rates of adverse reactions in the three groups were 17.07% in the combined group, 12.82% in the tiapride group, and 10.26 % in the clonidine group, 12.82% and 10.26% (P>0.05), and among the adverse events there were no critical serious events. Conclusion Thiopride hydrochloride, colistin transdermal patch, and the combination of treatment modalities have more objective efficacy in the therapeutic effect of tic disorders, and no critical adverse events and dangerous situation, but by combining thiopride hydrochloride and colistin treatment modalities can be better control of children's tic conditions within the same period of time, and the therapeutic effect is more accurate, and it is worth to be popularized.

Key words: tic disorders, tiapride hydrochloride tablets, colistin transdermal patch, neurological disease