Abstract: Objective To explore and analysis the correlation between preoperative serum levels of VE cadherin, angiopoietin-2 (Ang-2), and prognosis in patients with AMI undergoing PCI. Methods From March 2020 to October 2022,76 patients with acute myocardial infarction who were hospitalized in Inner Mongolia Baotou Steel Hospital, they were given percutaneous coronary intervention. serum VE-Cad and Ang-2 levels were tested before intervention, the prognosis of major cardiovascular adverse events in patients with follow-up was investigated, and then correlation analysis was performed. Results A total of 76 patients were followed up until April 1, 2023, with an average follow-up time of (18.57 ± 1.14) months. There were 12 cases of major cardiovascular adverse events (observation group, no major cardiovascular adverse events were classified as the traditional group) that accounted for 15.79%. Among them, 3 cases of recurrent myocardial infarction, 4 cases of malignant arrhythmia, 2 cases of stent thrombosis, 1 case of revascularization, 1 case of heart failure, and 1 case of cardiac death. The serum VE-Cad levels in the observation group were significantly lower than those in the traditional group (P<0.05), and the serum Ang-2 levels were significantly higher than those in the traditional group (P<0.05). Spearman correlation analysis showed there were correlation between pre PCI serum levels of VE-Cad and Ang-2 in patients with acute myocardial infarction and the occurrence of major cardiovascular adverse events (P<0.05). Logistic regression analysis showed that serum levels of VE-Cad and Ang-2 were important factors leading to the occurrence of major cardiovascular adverse events after PCI for acute myocardial infarction (P<0.05). Conclusion The incidence of major cardiovascular adverse events during follow-up after percutaneous coronary intervention in acute myocardial infarction is still relatively high. Patients with major cardiovascular adverse events are often accompanied by low expression of serum VE-Cad and high expression of serum Ang-2 before surgery. There are correlation between serum VE-Cad and Ang-2 levels before PCI in acute myocardial infarction and prognosis.

Key words: acute myocardial infarction, percutaneous coronary intervention, major cardiovascular adverse events, vascular endothelial cell cadherin, angiopoietin-2, relevance