Abstract: Objective To explore the application effect of Jianpi Yishen Recipe combined with Silymarin on AIDS of spleen and kidney deficiency type. Methods From May 2021 to May 2023, 80 patients with AIDS treated in Changzhou Third People's Hospital were selected as research objects, and they were randomly divided into an observation group and a control group, with 40 cases in each group. The control group patients were treated with conventional antiretroviral therapy combined with Silybin, while the observation group patients were treated with Jianpi Yishen Formula combined with Silybin on the basis of conventional antiretroviral therapy. The changes in traditional Chinese medicine syndrome scores, CD3⁺CD4⁺, CD3⁺CD8⁺, CD8⁺CD38⁺lymphocyte count, and liver and kidney function were compared between the two groups before and after treatment. Result Before treatment, there was no significant difference in the scores of traditional Chinese medicine syndromes related to soreness and weakness in the waist and knees, diarrhea, poor appetite, and fatigue between the two groups of patients (P>0.05). After treatment, the scores of traditional Chinese medicine syndromes related to soreness and weakness in the waist and knees, diarrhea, poor appetite, and fatigue in both groups of patients decreased, and the observation group was lower than the control group (P<0.05); Before treatment, there was no significant difference in the number of CD3⁺CD4⁺, CD3⁺CD8⁺, and CD8⁺CD38⁺ T lymphocytes between the two groups of patients (P>0.05). After treatment, the number of CD3⁺CD4⁺ T lymphocytes were increased in the two groups of patients, and the number of CD3⁺CD8⁺ T lymphocytes and CD8⁺CD38+ T lymphocytes were decreased in the observation group compared to the control group; the number of all T lymphocytes in the observation group was higher than that of the control group (P<0.05). Before treatment, there was no significant difference between the two groups in the levels of glutamic transaminase (ALT), glutamic transaminase (AST), blood creatinine (Scr) and urea nitrogen (BUN) (P>0.05). After treatment, the levels of ALT, AST, SCR and BUN in the two groups were lower than those in the control group (P<0.05). Conclusion The combination of Jianpi Yishen Recipe and Silymarin Bingan has a significant therapeutic effect on AIDS of spleen and kidney deficiency type, which can alleviate the clinical symptoms of patients, improve the immune function and liver kidney function, and is worthy of clinical application and promotion.

Key words: Jianpi Yishen Formula, Silymarin, spleen and kidney deficiency type, AIDS, liver function, renal function, T lymphocytes