Abstract: Objective To explore and analysis the correlation between platelet aggregation rate (PAR) and major cardiovascular adverse events (MACE) in patients with unstable angina. Methods From May 2021 to July 2022, 134 cases of patients with unstable angina who were hospitalized in the cardiovascular department of Kulle Hospital, Second Division, Xinjiang Production and Construction Corps were selected as the research subjects. The platelet aggregation rate of all patients at admission was measured, and the main cardiovascular adverse events of the patients were followed up and were give correlation analysis. Results All patients were followed up until May 1, 2023, with an average follow-up time of (24.10 ±1.93) months. There were 21 cases of major cardiovascular adverse events (MACE group) that accounted for 15.7%, included 3 cases of myocardial infarction, 1 case of cardiac death, 4 cases of heart failure, and 13 cases of stent thrombosis. There were no significant difference in sex, age, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, systolic blood pressure, diastolic blood pressure, smoking, alcohol consumption compared between the MACE group and the non MACE group (P>0.05). There were no significant difference in platelet count, platelet distribution width, average platelet volume, and platelet hematocrit compared between the two groups (P<0.05). The platelet aggregation rate in the MACE group were significantly higher than that in the non MACE group (P<0.05). In the 134 patients, Spearman correlation analysis showed a correlation between platelet aggregation rate and the occurrence of major cardiovascular adverse events (r=0.724, P<0.001). Multivariate logistic regression analysis showed that platelet aggregation rate was an important factor leading to major cardiovascular adverse events in patients with unstable angina during follow-up (P<0.05). Conclusion The incidence of major cardiovascular adverse events in patients with unstable angina is relatively high, and the occurrence of major cardiovascular adverse events is often accompanied by an increase in platelet aggregation rate. There is a correlation between platelet aggregation rate and the occurrence of major cardiovascular adverse events in patients with unstable angina.

Key words: unstable angina pectoris, major cardiovascular adverse events, platelet aggregation rate, relevance, low density lipoprotein cholesterol, intrastent thrombosis