Abstract: Objective To analyze the clinical effect of serum homocysteine (HCY) and lipoprotein-associated phospholipase A2 (Lp-PLA2) levels in the efficacy of oxygenation and blood transfusion after ischemic stroke. Methods A total of 80 patients with ischemic stroke admitted to Lingcheng District People's Hospital from December 2019 to December 2022 were selected as the study subjects, and served as the experimental group. At the same time, 80 healthy people were admitted at the same time were selected as the control group. The experimental group was divided into three subgroups according to National Institute of Health stroke scale (NIHSS), that is, mild subgroup (NIHSS<5 points), moderate subgroup (NIHSS 5~15 points) and severe subgroup (NIHSS≥15 points). The research was done retrospectively. The levels of serum HCY, Lp-PLA2 and LPA were compared between the two groups. At the same time, patients with ischemic stroke were treated with oxygenation and blood transfusion, and the levels of HCY, Lp-PLA2 and LPA before and after treatment were compared. Results The levels of HCY, Lp-PLA2 and LPA in the experimental group were significantly higher than those of the corresponding indices (P<0.05). The levels of HCY, Lp-PLA2 and LPA in severe nsubgroup were significantly higher than those of mild and moderate subgroups, and the levels of indicators above moderate subgroup were higher than those of mild subgroup (P<0.05). The levels of HCY, Lp-PLA2 and LPA in the experimental group after treatment were lower than those before treatment, and the difference was statistically significant before and after treatment (P<0.05). The plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, hematocrit and platelet adhesion rate of the experimental group after treatment were decreased significantlycompared with those before treatment (P<0.05). Conclusion The levels of serum HCY and Lp-PLA2 are higher in patients with ischemic stroke, and monitoring the levels of serum HCY and Lp-PLA2 during oxygenation and blood transfusion in patients with ischemic stroke can be used as an effective indicator for disease monitoring and prognosis evaluation.

Key words: ischemic stroke, oxygenation and blood transfusion, HCY, Lp-PLA2