The Clinical Feature and Treatment Prognosis of Amiodarone-Induced Pulmonary Toxicity

ZHONGHUA YANGSHENG BAOJIAN ›› 2024, Vol. 42 ›› Issue (3): 1-4.

The Clinical Feature and Treatment Prognosis of Amiodarone-Induced Pulmonary Toxicity

ZHANG Sen-sen^1,2,3,4, ZHANG Na-xin^1,2,3,4

1. Department of Respiratory Medicine, The Third Central Hospital of Tianjin, Tianjin 300170, China;
2. Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin 300170, China;
3. Artifical Cell Engineering Technology Research Center, Tianjin 300170, China;
4. Tianjin Institute of Hepatobiliary Disease, Tianjin 300170, China

Online:2024-02-01 Published:2024-01-23

Abstract

Abstract: Objective Amiodarone is the most commonly used antiarrhythmic drug, and interstitial pneumonia is its serious adverse reaction. This study aims to explore the clinical feature and treatment prognosis of amiodarone-induced diffuse interstitial pneumonia. Methods A case of amiodarone-induced diffuse interstitial pneumonia was retrospectively analyzed in terms of clinical manifestations, imaging feature, treatment and outcome. Results The elderly male patient appeared to have symptoms of cough, dyspnea after use of amiodarone for 1.5 months. The course of disease develops rapidly, followed by type Ⅰ respiratory failure. After symptomatic treatment, withdrawal of amiodarone, non-invasive ventilator assisted breathing, administration of hormones, the clinical symptoms disappeared. Conclusion The diagnosis of amiodarone-induced diffuse interstitial pneumonia should be based on medication history, combined with clinical and imaging findings. The key to successful treatment is to discontinue amiodarone, give corticosteroid and ventilator therapy in severe patients.

Key words: amiodarone, interstitial pneumonia, amiodarone-induced pulmonary toxicity

CLC Number:

R563.1

ZHANG Sen-sen, ZHANG Na-xin. The Clinical Feature and Treatment Prognosis of Amiodarone-Induced Pulmonary Toxicity[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(3): 1-4.

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