Efficacy of Fumigation and Washing Combined with Phototherapy in Treating Neonatal Jaundice and Its Influence on NSE and MBP Levels

Abstract

Abstract: Objective To study and analyze the efficacy of Fumigation and Washing combined with Phototherapy in the treatment of neonatal jaundice and its impact on NSE and MBP levels. Methods A total of 100 children with neonatal jaundice treated in Cangzhou Maternal and Child Health Hospital from October 2021 to March 2023 were selected as the research subjects. The children were randomly numbered, with the odd number set as the control group, and the even number set as the observation group, with 50 cases in each group.On the basis of blue light treatment, the control group took Yinzhihuang oral liquid for treatment, and the observation group received yellow withdrawal protocol for fumigation treatment. Observe and compare the bilirubin values, average daily sleep time and crying times, NSE and MBP levels before and after treatment, and family satisfaction of patients after treatment. Results There was no significant difference in percutaneous bilirubin values between the two groups before treatment (P>0.05), and the percutaneous bilirubin values decreased at 24 h, 48 h and 72 h after treatment, and the observation group decreased more than those in the control group, and the difference was statistically significant (P<0.05); After treatment, the sleep time in the observation group was higher than that in the control group, and the average crying frequency was lower than that in the control group, with a statistically significant difference (P<0.05); Before treatment, there was no statistically significant difference in the levels of NSE and MBP between the two groups (P>0.05). After treatment, the levels of NSE and MBP in both groups decreased, and after treatment, the levels of NSE and MBP in the observation group were significantly lower than those in the control group, with a statistically significant difference (P<0.05); After treatment, The satisfaction of the observation group was significantly higher than that of the control group,statistically significant (P<0.05). Conclusion Fumigation and washing combined with phototherapy have significant therapeutic effects on neonatal jaundice, improving children's sleep quality,reducing crying behavior,and reducing NSE and MBP levels.

Key words: return the yellow agreement party fumigation washing, phototherapy, jaundice of the newborn, NSE, MBP

CLC Number:

R722.17

ZHANG Wen-ru. Efficacy of Fumigation and Washing Combined with Phototherapy in Treating Neonatal Jaundice and Its Influence on NSE and MBP Levels[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(24): 31-34.

References

[1] 郭佳林,刘颖钏,沈莹,等.退黄合剂直肠滴注联合蓝光光疗对新生儿高胆红素血症疗效及血液学指标的影响[J].同济大学学报(医学版),2016,37(6):59-63.
[2] 《中成药治疗优势病种临床应用指南》标准化项目组.中成药治疗新生儿黄疸临床应用指南(2020年)[J].中国中西医结合杂志,2021,41(3):280-285.
[3] 姚志军,毕仲江,徐莎,等.茵栀黄口服液、贝飞达联合光疗治疗新生儿黄疸的临床疗效分析[J].现代生物医学进展,2013,13(20):3878-3880.
[4] 陈勇,张勤.消黄汤经验方和穴位按摩联合蓝光照射辨治湿热熏蒸型新生儿黄疸的临床效果[J].世界中医药,2018,13(1):112-115.
[5] 韩姗姗,陈文霞,苏素静,等.基于GRADE系统的茵栀黄口服液联合常规疗法治疗新生儿黄疸的循证分析[J].中成药,2019,41(2):321-326.
[6] 郭丹羽,顾坚,李堰松,等.光疗联合腹部按摩治疗新生儿黄疸的效果及对氧化应激和氧磷酶水平的影响[J].中国妇幼保健,2021,36(15):3494-3496.
[7] 刘鑫,马中岭,张长存.复方茵陈糖浆联合益生菌与间歇光疗治疗新生儿母乳性黄疸疗效观察[J].新乡医学院学报,2020,37(2):181-184.
[8] 任舒婷,顾晓慧,吴晓萍.自拟清热利湿退黄汤结合新生儿按摩抚触治疗新生儿黄疸的疗效观察[J].湖南中医药大学学报,2019,39(11):1391-1394.
[9] 梁正,谭惠元,利幸芝,等.新型新生儿中药退黄洗液治疗葡萄糖-6-磷酸脱氢酶缺乏症新生儿黄疸临床疗效观察[J].广西医学,2017,39(4):450-452.
[10] 李林. 健脾祛湿退黄汤药浴结合蓝光照射对新生儿黄疸血清白蛋白与非结合胆红素的影响[J].四川中医,2019,37(5):119-121.
[11] 霍静雨,雷东红,闫凡,等.四磨汤联合蓝光照射治疗新生儿黄疸的效果及对免疫功能的影响观察[J].贵州医药,2022,46(3):383-384.
[12] 熊昕,谭若琨,刘海峰,等.腺苷蛋氨酸联合白蛋白治疗新生儿黄疸的临床疗效及对血清γ-谷氨酰转移酶,胰岛素样生长因子水平的影响[J].现代生物医学进展,2020,20(17):3278-3281,3220.
[13] 陈芳芳,李崇寿,倪王平.益生菌联合蓝光照射治疗新生儿黄疸的临床效果及对患儿营养状况的改善作用[J].中国妇幼保健,2022,37(6):1012-1014.
[14] 侍海棠,杨婷婷,刘静,等.早期间歇蓝光照射联合益生菌黄疸茵陈颗粒治疗新生儿黄疸对免疫能力黄疸指数及临床疗效的影响[J].河北医学,2022,28(6):924-929.
[15] 彭研献,董晓斐,周娅微,等.茵栀黄口服液联合枯草杆菌二联活菌颗粒辅助治疗新生儿黄疸的疗效及对免疫功能和生长发育的影响[J].现代生物医学进展,2021,21(19):3748-3751,3800.
[16] 马岩,顾岚,高丽,等.蓝光照射联合茵栀黄颗粒治疗新生儿黄疸的疗效观察及安全性分析[J].世界中医药,2019,14(12):3237-3240.
[17] 刘俊,陈琦,白如君.血清IGF-1、NSE、MBP联合检查对新生儿黄疸脑损伤的诊断价值[J].临床和实验医学杂志,2020,2(22):2447-2450.