Abstract: Objective The relationship of serum gastrin-releasing peptide precursor (proGRP) combined with neutrophil/lymphocyte ratio (NLR) on lymph node metastasis and the diagnosis of thyroid cancer were analyzed. Methods The 140 patients with thyroid nodules admitted to Xi'an Aerospace General Hospital between January 2020 and January 2023 were selected as the study object, with pathological results as the gold standard, 70 patients with thyroid cancer were taken as the observation group, the other 70 patients with benign thyroid nodules as the control group, and the patients were divided into metastasis group (n=33) and non metastasis group (n=37). The diagnostic efficacy of serum proGRP and NLR in thyroid cancer and lymph node metastasis was calculated by comparing the difference of serum proGRP and NLR index values respectively. Results The proGRP and NLR values of patients in observation group were higher than those of control group, the difference was statistically significant(P<0.05), and the serum proGRP and NLR values of patients in metastasis group were higher than those of non-metastasis group, and the difference was statistically significant(P<0.05); the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of serum proGRP and NLR index were respectively higher than that of each index alone, and the difference was statistically significant(P<0.05); the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of serum proGRP combined with NLR index to predict thyroid cancer with lymph node metastasis were higher than that of each index alone, and the difference was statistically significant(P<0.05). Conclusion Serum proGRP combined with NLR has high diagnostic value for thyroid cancer, and the two are closely related to thyroid cancer with lymph node metastasis, so the index detection in advance has certain predictive value for the risk of lymph node metastasis.

Key words: Serum gastrin releasing peptide precursor, Neutrophil/lymphocyte ratio, Thyroid cancer, Lymph node metastasis