Abstract: Objective To explore and analysis the diagnostic values of contrast-enhanced ultrasound combined with vaginal color Doppler ultrasound in endometrial lesions of postmenopausal vaginal bleeding. Methods From December 2019 to December 2022, 89 cases of patients with postmenopausal vaginal bleeding and endometrial lesions who were diagnosed and treated in our hospital were selected as the study subjects. All patients were examined with contrast-enhanced ultrasound combined with vaginal color Doppler ultrasound, and the ultrasonic characteristics were recorded. Pathological examination was taken as the gold standard, and the diagnostic value was judged. Results In the 89 patients, there were 69 cases were diagnosed as benign lesions (23 cases of endometrial hyperplasia, 17 cases of hysteromyoma, 29 cases of endometrial polyps, benign group) and 20 cases as malignant lesions (endometrial cancer, malignant group). The blood flow resistance index, peak systolic velocity and pulsation index in benign group were significantly higher than those in malignant group (P<0.05). The average transit time of contrast agent in the benign group was significantly shorter than that in the malignant group (P<0.05), and there was no significant difference compared between the two groups in terms of development time, peak time and peak intensity (P>0.05). In the 89 patients, the diagnostic coincidence rate of color Doppler ultrasound was 87.64%, the diagnostic coincidence rate of contrast-enhanced ultrasound was 86.52%, the diagnostic coincidence rate of contrast-enhanced ultrasound combined with vaginal color Doppler ultrasound was 98.88%, and the diagnostic coincidence rate of contrast-enhanced ultrasound combined with vaginal color Doppler ultrasound were significantly higher than that of single method (P<0.05). Conclusion The combination of contrast-enhanced ultrasound and vaginal color Doppler ultrasound has high diagnostic value for endometrial lesions of postmenopausal vaginal bleeding, which is worthy of clinical application.

Key words: contrast-enhanced ultrasound, color Doppler ultrasound of vagina, postmenopausal vaginal bleeding, endometrial lesions, diagnostic coincidence rate, peak systolic velocity, average transit time of contrast agent