Clinical Efficacy Observation of Tibetan Fenugreek Granules on Pre-Diabetes Mellitus

Abstract

Abstract: Objective To investigate the clinical effectiveness of Fenugreek in patients with pre-diabetes. Methods The selected 100 patients with pre-diabetes who get medical treatment in the 5 hospitals were randomly divided into 3 groups used the random number table method: comparison group (20 cases), the treatment group with placebo (40 cases),the treatment group with fenugreek (40 cases). They all were applied with diabetes life intervention education. The other two treatment groups with placebo and fenugreek additionally took placebo or fenugreek one-to-one correspondence. Observe records and compare waist circumference (WC), body mass index (BMI), glycosylated hemoglobin A1c (HbA_1c), fasting plasma glucose (FPG), oral glucose after 2 hours blood glucose (2 hPG), triglyceride (TG) of pertherapy and post-treatment of the 3 groups. Result Compared with those of pertherapy,the observation indexes were decreased in all groups. Compared with the other two groups, the levels of WC, BMI, HbA_1c, FPG, 2 hPG, TG of the treatment group with fenugreek decreased more obviously (P<0.05). Conclusions Fenugreek granule is effective to pre-diabetes and it is worth being used widely in clinical practice．

Key words: tibetan medicine, fenugreek, pre-diabetes

CLC Number:

R587.1

NING Xue-feng, CHEN Qing, SUN Dan-feng. Clinical Efficacy Observation of Tibetan Fenugreek Granules on Pre-Diabetes Mellitus[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(19): 1-4.

References

[1] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2020版)[J].中华糖尿病杂志,2021,13(4),316-317.
[2] YANG W Y, LU J M, WANG J P, et al.Prevalance of diabetes among men and women in China[J]. N Engl J Med,2010,362(12):1090-1101.
[3] 王艺润,赵存花,汪满江措,等.藏医藏药对糖尿病的认识与治疗[J].中国民族医药杂志,2013,19(10):33-35.
[4] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017版)[J].中华糖尿病杂志,2018,10(1):4-67.
[5] 仲格嘉. 藏医对2型糖尿病的认识和治疗探析[J].中国藏学,2014 (2):152-155.
[6] MARKER R E, WAGNER R B, ULSHAFER P R, et al.New sources for sapogenins[J]. Journal of the American Chemical Society,1947,69(9):2242.
[7] 杨玲,马玉静,肖定福,等.葫芦巴生物学功能研究进展及其应用[J].动物营养学报,2020,32(1):62-70.
[8] 周聪,沈霖,陈瑞,等.葫芦巴改善瘦素缺陷型ob/ob小鼠炎症及胰岛素抵抗的机制研究[J].中西医结合研究,2022,14(4):234-238.
[9] 刘子怡. 葫芦巴籽中葫芦巴碱的提取及应用研究进展[J].现代盐化工,2021,8(4):8-9.
[10] 刘永巧,魏颖,高佳琪,等.葫芦巴碱对HepG₂细胞胰岛素抵抗的影响[J].中医药导报,2018,24(4):7-10.
[11] PRAVEEN K K, CHRISTOFER T, RAGHU J, et al.Fenugreek seed extract ameliorates cognitive deficits in streptozotocin-induced diabetic rats[J]. Nephron Clinical Practice,2019,30(4):184-90.
[12] 黄慧,王霞,贺建华,等.葫芦巴活性成分提取工艺及其生物活性作用研究进展[J].中兽医医药杂志,2021,40(5):37-40.
[13] 阮耀,黄川锋.葫芦巴对糖尿病大鼠肾脏保护作用的实验研究[J].中国中医药科技,2008,15(6):432-433.
[14] 姜明月,叶斌斌,曲杨,等.胡芦巴生制品降血脂功效研究[J].药学研究,2020,39(12):693-696.