Abstract: Objective To investigate the effect of Jiawei Liujunzi Decoction in treating tic disorder of spleen deficiency and phlegm accumulation type. Methods A total of 76 children with tic disorder of spleen deficiency and phlegm accumulation type admitted to the pediatric clinic of Weifang Hospital of traditional Chinese medicine 10.2021~5.2022 were seperated into two groups by random numbers. 38 cases in the control group were treated with tiapride hydrochloride tablets; 38 cases in the observation group were treated with Jiawei Liujunzi Decoction. Duration of two groups’ treatment were 8 weeks. The score of YGTSS, TCM symptoms, the levels of neurotransmitters, T lymphocyte subsets, vitamin A and vitamin D were detected and compared. Results The YGTSS and TCM symptom score of the children treated with Jiawei Liujunzi Decoction were lower than those treated with tiapride after treatment (P<0.05). The levels of IL-6, 5-HT and dopamine in the two groups after treatment were lower than those before treatment, GABA was higher than that before treatment, the range of changes in these indicators in the observation group were more remarkable than those in the control group after treatment (P<0.05). After treatment, the levels of CD3⁺、CD4⁺、CD4⁺/CD8⁺ in the two groups were raised than 8 weeks before, and the levels of CD8⁺ were lower than 8 weeks before. The range of changes in these indicators in the observation group were more remarkable than those in the control group after treatment (P<0.05).The levels of Vit A and Vit D in the observation group were higher than those in the control group (P<0.05). Conclusion Jiawei Liujunzi Decoction has a more effective therapeutic effect on the tic symptoms of spleen deficiency and phlegm accumulation, and has a better effect on the level of neurotransmitters and immune function of children, which is worthy of clinical application.

Key words: tic disorder, Jiawei Liujunzi Decoction, tiapride hydrochloride tablets, spleen deficiency and phlegm accumulation type