Abstract: Objective To explore the clinical effect of donepezil hydrochloride combined with repetitive transcranial magnetic stimulation on patients with Alzheimer disease. Methods 96 patients with Alzheimer disease who were treated in Linyi Mental Health Center from January 2021 to October 2022 were selected as the subjects of this study. They were randomly divided into two groups with 48 patients each. The control group was treated with oral donepezil hydrochloride, and the experimental group was treated with repeated transcranial magnetic stimulation on the basis of the control group. The cognitive function, activities of daily living (ADL) and sleep quality of the two groups were observed before and after treatment. Results Mini-mental State Examination (MMSE) of the two groups before intervention was compared (P>0.05); after the intervention, the MMSE score of patients in the two groups was higher than that before the intervention, and the MMSE score in the experimental group was higher than that in the control group (P<0.05). ADL score and Pittsburgh Sleep Quality Index (PSQI) score between the two groups were compared before intervention, with no significant difference (P>0.05); after the intervention, the ADL score and PSQI score of the two groups were lower than those before the intervention, and the ADL score and PSQI score of the experimental group were lower than those of the control group (P<0.05). Conclusion The application of donepezil hydrochloride combined with repetitive transcranial magnetic stimulation in patients with Alzheimer disease can effectively improve the mental state, daily living ability and sleep quality of patients, which is worthy of clinical application.

Key words: donepezil hydrochloride, repetitive transcranial magnetic stimulation, Alzheimer disease