Abstract: Objective To explore the self-knowledge and delivery related factors of pregnant women with chronic hepatitis B. Methods A total of 281 patients with pregnancy complicated with chronic hepatitis B were randomly selected from the First People's Hospital of Lianyungang City from February 2020 to August 2022. A questionnaire survey was conducted on all patients to understand their cognitive status of pregnancy complicated with chronic hepatitis B. Univariate and multivariate analysis was conducted at the same time to identify patients' concerns. According to the birth history, the patients with chronic hepatitis B were divided into the first pregnancy patients and the patients with birth history. Results The results of the questionnaire showed that the cognitive score of mother-to-child transmission of chronic hepatitis B during the first pregnancy, the cognitive score of hepatitis B virus related, and the score of prevention knowledge were shorter than those of the patients with childbirth history, and the difference was statistically significant (P<0.05). Univariate analysis showed significant differences in age, birth history, education level, chronic hepatitis B screening history and other factors, with statistical significance (P<0.05). Multiple logistic regression analysis showed that age, education level, chronic hepatitis B screening history and delivery history were factors influencing the knowledge of mother-to-child transmission in pregnant patients with chronic hepatitis B (P<0.05). Patients were significantly more concerned about breast-feeding, drug safety, blocking methods and success rates, and available treatments. Conclusion In pregnancy with chronic hepatitis B questionnaire survey showed that patients with labor history multiple cognitive score significantly higher, there are many factors can affect the patient's cognitive ability, patients focus on safety, breastfeeding, treatment, blocking the success rate of several problems, in the clinical need for prevention and the corresponding intervention.

Key words: pregnancy, chronic hepatitis B, self knowledge, delivery, related factors