Abstract: Objective To investigate the efficacy of Xiyanping combined with second-generation penicillin in the treatment of scarlet fever and the effect on the positive rate of group A streptococcus. Methods 100 children with scarlet fever admitted to Jilin Children's Hospital from January 2017 to December 2020 were selected as the research object, and were divided into two groups with 50 cases in each group by random number table method. The children in the control group received routine intravenous drip of the first generation penicillin, while the children in the observation group received intravenous drip of the second generation penicillin combined with Xiyanping to compare the clinical efficacy of the two groups, the sleep quality score, scarlatina symptom score, symptom improvement and recovery time of the children after treatment, and the positive rate of group A streptococci before and after treatment and adverse reactions. Results After treatment, the total effective rate in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). After treatment, the positive expression of GAS strain, SpeC strain and SpeA strain of emm gene in the two groups decreased significantly, and the positive expression in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). There was no difference in sleep quality scores and scarlet fever symptoms between the two groups before treatment, the difference was not statistically significant (P>0.05). After treatment,the scores of the above two indicators in the two groups had a significant downward trend, and the scores in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). At the same time, the recovery time and symptom improvement time of the children in the observation group were also significantly lower than those in the control group,and the difference was statistically significant (P<0.05). There was no difference in the incidence of adverse reactions between the two groups, the difference was not statistically significant (P>0.05). Conclusion The second-generation penicillin has a significant effect on scarlet fever, which can reduce the positive rate of group A streptococcus, quickly reduce the clinical symptoms of children, and improve the sleep quality. At the same time, it also has A high safety, and has certain application value in clinical practice, and can be promoted.

Key words: xi yanping, second generation penicillin, scarlet fever, acute respiratory infection, group a streptococci, adverse reactions