Effect of Esketamine Combined with Dextrmedetomidine Anesthesia on Stress Response and Resuscitation Quality in Children Undergoing Laparoscopic Surgery

Abstract

Abstract: Objective To investigate the effect of esketamine combined with dexmedetomidine anesthesia on stress response and resuscitation quality in children undergoing laparoscopic surgery. Methods From January 2021 to January 2022, 96 cases of children who underwent laparoscopic high ligation of inguinal hernia sac in Maternal and Child Health Hospital of Inner Mongolia Autonomous Region were selected as research objects. Accorded to the 1:1 random number table, the children were divided into the combined group and the control group with 48 cases in each groups. The control group was anesthetized with ketamine, the combined group was anesthetized with dexmedetomidine on the basis of the control group, and the anesthesia conditions of the combined group and the control group were recorded, the changes of serum epinephrine and Glucagon levels at different time points, the scores of restlessness in the awakening period, and the occurrence of adverse reactions on the 7th day after operation. Results There were no significant difference in the onset time of anesthesia compared between the two groups (P>0.05). The recovery time, ketamine dosage, and hospital stay after surgery in the combined group were less than those in the control group(P<0.05). The content of serum adrenaline and glucagon in the two groups when they were sent back to the ward were significantly lower than that when they entered the operating room (P<0.05), and the content of serum adrenaline and glucagon in the combined group were also significantly lower than that in the control group (P<0.05). The PAED score of restlessness in the combined group were significantly lower than that in the control group (P<0.05). The incidence of adverse reactions, such as nausea and vomiting, respiratory depression, tachycardia, and hypoxemia at 7 d after the combination group, was 4.17%, which was not significant compared with 8.33% in the control group (P>0.05). Conclusion The application of esketamine combined with dexmedetomidine anesthesia in pediatric laparoscopic surgery can alleviate stress reaction, promote the recovery and rehabilitation of children, reduce the dosage of ketamine, improve the restlessness of children during the recovery period, and will not increase the occurrence of adverse reactions.

Key words: esketamine, dextrmedetomidine, laparoscopic surgery, restlessness during awakening, stress reaction

CLC Number:

R726.1

YANG Qiang, FAN Chao. Effect of Esketamine Combined with Dextrmedetomidine Anesthesia on Stress Response and Resuscitation Quality in Children Undergoing Laparoscopic Surgery[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(11): 166-169.

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