Abstract: Objective To explore the predictive value of angiopoietin like protein 3 (ANGPTL3) and serum myostatin (Myostatin) on hypoglycemia in diabetes neonates during pregnancy. Methods 80 patients with gestational diabetes admitted to Ya'an Traditional Chinese Medicine Hospital in Sichuan Province from January 2018 to October 2022 were selected for retrospective analysis, and they were divided into the observation group. In addition, 80 healthy pregnant women volunteers who came to Ya'an Traditional Chinese Medicine Hospital in Sichuan Province for physical examination in the same period were selected as the control group. The expression levels of ANGPTL3 and Myostatin in the two groups of pregnant women were compared, and the correlation between ANGPTL3, Myostatin and gestational diabetes was analyzed. Then we collected the postpartum data of 80 cases of pregnancy diabetes patients, excluded 3 cases of premature delivery and 1 case of stillbirth, and divided the remaining 76 cases of pregnancy diabetes patients who successfully delivered the fetus into two groups according to whether the newborn had hypoglycemia, divided 50 cases of neonatal hypoglycemia into neonatal hypoglycemia group, and divided 26 cases of patients who did not have neonatal hypoglycemia into non neonatal hypoglycemia group, and compared the two groups of patients with ANGPTL3. The expression level of Myostatin and the general clinical situation were analyzed by Logistic regression analysis. Results The levels of ANGPTL3 and Myostatin in the observation group during pregnancy were significantly higher than those in the control group (P<0.05); Pearson correlation analysis showed that ANGPTL3 and Myostatin were positively correlated with the severity of gestational diabetes (P<0.05); There was no significant difference between the neonatal hypoglycemia group and the non neonatal hypoglycemia group in the history of spontaneous abortion, age, BMI before pregnancy, and gestational weeks of delivery of diabetes patients during pregnancy (P>0.05), but there were significant differences in the family history of diabetes, empty blood glucose, blood glucose 1 hour after meal, blood glucose 2 hours after meal, ANGPTL3, and Myostatin levels (P<0.05); Logistic regression analysis showed that ANGPTL3 and Myostatin were independent risk factors for hypoglycemia in diabetes neonates during pregnancy (P<0.05). Conclusion ANGPTL3 and Myostatin have a certain correlation with the occurrence and development of diabetes in pregnancy. In addition, the level of ANGPTL3 and Myostatin in pregnancy can predict the occurrence of neonatal hypoglycemia. Therefore, it is necessary to take relevant measures to prevent neonatal hypoglycemia in time during production, or to supplement glucose in time after delivery of such newborns.

Key words: angiopoietin like protein 3, serum muscle somatostatin, gestational diabetes, neonatal hypoglycemia