Clinical Efficacy of Tovaptan in Treating Hyponatremia after Aneurysmal Subarachnoid Hemorrhage

Abstract

Abstract: Objective To evaluate the efficacy and safety of tovaptan in the treatment of hyponatremia after aneurysmal subarachnoid hemorrhage. Methods 68 patients with aneurysmal subarachnoid hemorrhage admitted to our hospital from January 1, 2020 to June 30, 2022 were retrospectively analyzed. According to the treatment methods of patients, 35 patients who were treated with hypertonic saline were divided into hypertonic saline group, 33 patients who were treated with tolvaptan were divided into tolvaptan group. The clinical baseline data of the two groups, changes in blood sodium level and treatment, changes in NIHSS score at different times, and the comparison of adverse reactions in the course of treatment were analyzed. Results There was no significant difference in the blood sodium level between the two groups before treatment (P>0.05). The blood sodium level in the two groups increased significantly from 24 hours after treatment to discharge, but the level in the tolvaptan group was significantly higher than that in the hypertonic saline group. At the same time, the incidence of hyponatremia in the tolvaptan group at discharge and the need to receive treatment again 24 hours later was significantly lower than that in the hypertonic saline group (P<0.05); There was no difference in the NIHSS score between the two groups before treatment, and all time point after treatment. The 24-hour tolvarutan group was slightly lower than the hypertonic saline group (P>0.05), and 3 days was significantly lower than the tolvarutan group (P<0.05), but there was no difference between the two groups at discharge (P>0.05); one patient in the hypertonic saline group increased blood sodium too rapidly and improved after intervention. There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion The treatment of hyponatremia after aneurysmal subarachnoid hemorrhage has a significant effect, which significantly reduced the blood sodium level of patients, and reduced the nerve damage of patients, with high safety.

Key words: tovaptan, aneurysmal subarachnoid hemorrhage, hyponatremia, clinical efficacy, security

CLC Number:

R969

Saiyinbayaer. Clinical Efficacy of Tovaptan in Treating Hyponatremia after Aneurysmal Subarachnoid Hemorrhage[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(11): 44-47.

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