Research Progress on the Mechanism of Silencing Information Regulator 1 on Cartilage Injure Repair

Abstract

Abstract: Cartilage is vulnerable to be damaged by internal and external environmental, but its self-repair ability is limited due to the lack of nerves, blood vessels and lymphatic tissues. In this process, longevity gene silencing information regulator 1 (SIRT1) plays an important role. After cartilage damage, cartilage anabolism and catabolism are disordered. SIRT1 gene can regulate the process of cartilage damage by influencing chondrocyte inflammation, oxidative stress and other factors. In the molecular mechanism, SIRT1 gene plays an important role in regulating cartilage homeostasis, which can be mediated by Notch, BMP, Wnt/ β-Catenin and other signal pathways that play a regulatory role in cartilage damage repair. In this review, we illustrate the protective effects of SIRT1 on cartilage under pathophysiological conditions and its possible molecular biological mechanisms, providing theoretical support for research related to restoring cartilage homeostasis and achieving cartilage metabolic balance.

Key words: silencing information regulator 1, cartilage repair, signal pathway, pathogenesis

CLC Number:

R684

CHEN Yi-xiao, LI Guo-qing, LIU Su, WENG Jian, ZHU Yuan-chao, YU Fei, ZENG Hui. Research Progress on the Mechanism of Silencing Information Regulator 1 on Cartilage Injure Repair[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(3): 1-4.

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