Abstract: Objective To investigate the effects of stent thrombectomy on the levels of vascular endothelial growth factor and D-dimer in patients with acute ischemic stroke. Methods From January 2019 to February 2022, 84 cases of patients with anterior circalation infarction diagnosed and treated in Affiliated Hospital of Xuzhou Medical University were selected as the research subjects. According to the treatment method, the patients were divided into a thrombolysis group and a stent thrombectomy group, with 42 cases in each group. The stent thrombectomy group was given interventional therapy with stent thrombectomy, and the thrombolysis group was given intravenous thrombolysis. The changes in the expression levels of vascular endothelial growth factor and D-dimer in the two groups were detected. Results After treatment, the total effective rates of stent thrombectomy group were significantly higher than thrombolysis group (P<0.05). The peak systolic velocity (PSV) and end-diastolic velocity (EDV) of the middle cerebral artery in the two groups at treatment were significantly higher than those before treatment (P<0.05), and the stent thrombectomy group were significantly higher than the thrombolysis group (P<0.05). The levels of serum vascular endothelial growth factor and D-dimer in the two groups after treatment were significantly lower than those before treatment (P<0.05). The stent thrombectomy group were also significantly lower than the thrombolysis group (P<0.05). The incidence rates of cerebral transitional perfusion, venous thrombosis, infection and other complications in the stent thrombectomy group during the observation period were significantly lower than that in the thrombolysis group (P<0.05). Conclusion The application of stent thrombectomy in patients with cerebral infarction can inhibit the expression of serum vascular endothelial growth factor and D-dimer, it can also improve the blood flow velocity of the middle cerebral artery, thereby improving the overall treatment effect and reducing the incidence of complications.

Key words: stent thrombectomy, acute ischemic stroke, vascular endothelial growth factor, D-dimer, blood flow velocity, thrombolysis