Efficacy of Dahuang Mudan Decoction in the Treatment of Advanced Metastatic Colorectal Cancer

Abstract

Abstract: Objective To investigate the curative effect of Dahuang Mudan Decoction in the treatment of advanced metastatic colorectal cancer and its influence on the level of serum tumor markers. Methods A total of 60 patients with advanced metastatic colorectal cancer who were admitted to Yangzhou Hospital of Traditional Chinese Medicine from January 2018 to December 2020 were selected as the subjects. All the cases were divided into the experimental group and the control group with 30 cases each groups accorded to the 1:1 random envelope drawing principle, the control group group were given conventional chemotherapy, and the experimental group were given Dahuang Mudan Decoction on the basis of the conventional chemotherapy group's treatment. The curative effects of the two groups were observed, the toxic and side effects of the patients were observed during the treatment, the serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 242 contents were detected before and after treatment, and the patients were evaluated for Karnofsky score before and after treatment (karnofsky performance status, KPS), followed up for 1 year after treatment, and recorded the survival of patients. Results After treatment, the total effective rate of the experimental group were higher than the control group (P<0.05). During treatment, the incidence of nausea and vomiting, anemia,leukopenia, and neutropenia in the texperiental group were lower than those in the control group (P<0.05). The KPS scores of the experimental group and the control group after treatment were higher than those before treatment, and the experimental group was higher than the control group (P<0.05). Serum CEA and CA242 levels after treatment in the two groups were lower than before treatment (P<0.05), and the experimental group were lower than the control group (P<0.05). All patients were followed up for 1 year, and the median survival time and median progression-free survival of the experimental group were longer than those of the control group (P<0.05). Conclusion Dahuang Mudan Decoction in the treatment of advanced metastatic colorectal cancer can improve the therapeutic effect, reduce the occurrence of toxic and side effects, inhibit the release of serum CEA and CA242, improve the quality of life of patients, and prolong the survival time of patients.

Key words: Dahuang Mudan Decoction, advanced metastatic colorectal cancer, adverse reaction, tumor markers, quality of life

CLC Number:

R735.35

WANG Qing-ying. Efficacy of Dahuang Mudan Decoction in the Treatment of Advanced Metastatic Colorectal Cancer[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(21): 13-16.

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