Effects of Recombinant Human Prourokinase Intravenous Thrombolysis on Coronary Blood Flow in Patients with Stress STEMI and Myocardialperfusion

Abstract

Abstract: Objective To investigate the effects of intravenous thrombolysis with recombinant human urokinase on coronary blood flow and myocardial perfusion in patients with ST segment elevation myocardial infarction. Methods From January 2019 to January 2022, 120 patients with high thrombotic load acute ST segment elevation myocardial infarction (STEMI) treated in Xinjiang production and Construction Corps Hospital were randomly divided into study group and control group, with 60 cases in each group. Patients in the study group were treated with recombinant human urokinase and patients in the control group were treated with urokinase. The cardiac function index, coronary blood flow, myocardial perfusion and the incidence of cardiovascular adverse events were compared between the two groups. Results There was no statistical significant difference in left ventricular end systolic diameter (LVESD), left ventricular end diastolic diameter (LVEDd) and left ventricular ejection fraction (LVEF) between the two groups before and after treatment (P>0.05). After treatment, LVESD, LVEDd and LVEF were significantly improved (P<0.05), and there was no statistical significant difference between the two groups (P>0.05); There was no statistical significant difference in grade 0-1(P>0.05), grade 2 and grade 3 coronary artery blood flow between the two groups before treatment (P<0.05), and there was no significant difference in grade 0-1 coronary artery blood flow between the observation group after treatment(P>0.05). The number of grade 2 coronary artery blood flow in the observation group was lower than that in the control group, and the number of grade 3 coronary artery blood flow in the observation group was higher than that in the control group (P<0.05); The rate of ST treatment decline and myocardial staining grade (MBG) 3 in the two groups were significantly higher than those in the control group (P<0.05), CTFC (corrected TIMI frame number) and NR (no reflow) incidence were significantly lower than those in the control group (P<0.05); There was no statistical significant difference in the total incidence of adverse cardiovascular events between the two groups (P>0.05). Conclusion Intravenous thrombolysis with recombinant human urokinase can improve vascular recanalization, coronary blood flow and myocardial perfusion. The effect is positive and the safety is good. It is worthy of clinical application.

Key words: intravenous thrombolysis, recombinant human prourokinase, STEMI, coronary blood flow, myocardial perfusion

CLC Number:

R714.525

GUO Xue-feng. Effects of Recombinant Human Prourokinase Intravenous Thrombolysis on Coronary Blood Flow in Patients with Stress STEMI and Myocardialperfusion[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(17): 21-23.

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