Effects of Benazepril Combined with Labetalol on Vascular Endothelial Function and Carotid Intima-media Thickness in Patients with Hypertension

Abstract

Abstract: Objective To investigate the effect of benazepril combined with labetalol on vascular endothelial function and carotid intima-media thickness in patients with hypertension. Methods Selected 300 cases of patients with who were treated in Xinjiang Production and Construction Corps Hospitalfrom January 2019 to December 2021, the random number table method is divided into two groups.The control group was treated with labetalol alone, and the observation group was treated with benazepril combined with labetalol.The clinical efficacy, pulse pressure difference, diastolic blood pressure, carotid intima-media thickness (IMT) and systolic blood pressure were compared between the two groups,and systolic blood pressure were compared between the two groups, and the levels of serum ischemia modified albumin (IMA), nitric oxide (NO), endothelin-1 (ET-1), homocysteine (Hcy) and myeloperoxidase (MPO) were measured. Results The effective rate of the observation group wassignificantly higher than control group (P<0.05). Before treatment, there was no significant difference in blood pressure and pulse pressure difference between the two groups (P>0.05). After treatment, the blood pressure and pulse pressure difference between the two groups decreased significantly (P<0.05), and the observation group was lower (P<0.05). Before treatment, there was no significant difference in the levels of serum ET-1, Hcy, NO, IMA and MPO between the two groups (P>0.05). After treatment, the levels of serum ET-1, Hcy, IMA and MPO decreased significantly (P<0.05) and NO increased significantly (P<0.05). The levels of serum ET-1, Hcy, NO, IMA and MPO in the observation group were significantly better than those in the control group (P<0.05). Before treatment, there was no significant difference in carotid IMT between the two groups (P>0.05). After treatment, the carotid IMT of the two groups decreased significantly (P<0.05), and the carotid IMT of the observation group was lower (P<0.05). Conclusion Benazepril combined with labetalol can improve vascular endothelial function, reduce carotid IMT and improve curative effect in patients with hypertension.

Key words: benazepril, labelor, hypertension, vascular endothelial function, carotid intima-media thickness

CLC Number:

R544

Guo Xue-feng. Effects of Benazepril Combined with Labetalol on Vascular Endothelial Function and Carotid Intima-media Thickness in Patients with Hypertension[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(15): 4-5.

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