Abstract: Objective To investigate the relationship between serum inflammatory indexes, blood lipid and blood glucose and prognosis of stable coronary heart disease. Methods One hundred and twenty patients with stable coronary heart disease treated in our hospital from February 2019 to February 2022 were selected as the research object. All patients were divided into groups according to the levels of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), triglyceride (TG) and fasting blood glucose (FPG).The median level of IL-6 in all patients was 2.1 ng/L, which were divided into <2.1 ng/L group (n= 54) and ≥2.1 ng/L group (n=66). The median level of hs-CRP was 1.3 mg/L, which was divided into <1.3 mg/L group (n=58) and ≥1.3 mg/L group (n=62). According to the level of TG, it was divided into <1.7 mmol/L group (n=45) and >1.7 mmol/L group (n=75), and according to the level of FPG, it was divided into <7.0 mmol/L group (n=52) and >7.0 mmol/L group (n=68). The clinical characteristics and prognosis of patients with different levels of IL-6, hs-CRP, TG and FPG were compared. Cox regression analysis was used to analyze the clinical characteristics and prognosis of IL-6, hs-CRP, TG Correlation between FPG and prognosis of patients with stable coronary heart disease. Results There were statisticalsignificant differences in cardiovascular death, renal insufficiency, myocardial infarction, heart failure, and heart failure readmission in patients with different IL-6 levels (P<0.05). There were statisticalsignificant differences in hypertension, cardiovascular death, renal insufficiency, myocardial infarction, heart failure, and heart failure readmission in patients with different hs-CRP levels (P<0.05). There were statisticalsignificant differences in renal insufficiency and heart failure readmission in patients with different TG levels (P<0.05). There were statisticalsignificant differences among patients with diabetes mellitus, renal insufficiency, and heart failure readmissions among patients with different FPG levels (P<0.05). The results of regression analysis showed that high levels of IL-6, hs-CRP, TG and FPG were independent factors affecting the poor prognosis of stable coronary heart disease (P<0.05).Conclusion IL-6 and hs-CRP are independent risk factors for cardiovascular death, myocardial infarction, heart failure and readmission of heart failure in patients with stable coronary heart disease. IL-6 and hs-CRP may be involved in the pathophysiological process of these events, while TG and FPG levels are mostly independent risk factors for readmission of renal insufficiency and heart failure.

Key words: stable coronary heart disease, inflammatory index, blood glucose, blood lipids, heart failure