Abstract: Objective To analyze the diagnostic value of hemoglobin a_1c (HbA_1c), hemorheology index and coagulation index in type 2 diabetes mellitus (T2MD) patients with microangiopathopathy. Methods 200 patients with type 2 diabetes admitted to Rizhao Maternal and Child Health Hospital from April 2023 to April 2024 were divided into control group (n=110) and microangiopathopathy group (n=90) according to whether they had microangiopathopathy. HbA_1c, plasma viscosity(PV), whole blood viscosity, erythrocyte sedimentation rate (ESR), mean platelet volume (MPV) and platelet distribution width (PDW) were compared between the two groups. The risk factors of microangiopathopathy in T2MD patients were analyzed, and the receiver operating characteristic curve (ROC) was plotted, and the area under the curve (AUC) was used to evaluate the diagnostic value. Results HbA_1c, PV, whole blood high tangential viscosity, whole blood low tangential viscosity, ESR, FIB, MPV and PDW in microvascular disease group were higher than those in control group, the difference was statistically significant (P<0.05). Logistic regression analysis showed that HbA_1c, PV, whole blood low tangency viscosity and FIB were all risk factors for the complication of microangionopathy in T2MD patients(P<0.05). The AUC values of HbA_1c, PV, whole blood low tangency viscosity, FIB and the combination of HBA_1c and PV were 0.799, 0.802, 0.841, 0.797, 0.907, respectively (P<0.05), and the AUC values of the combination of HBA_1c and PV were higher(P<0.05). Conclusion HbA_1c, PV, whole blood low tangential viscosity and FIB are the risk factors for T2MD complicated with microangularity, and the combination of the four factors is more helpful for the diagnosis of T2MD complicated with microangularity.

Key words: glycosylated hemoglobin A_1c, hemorheology, blood clotting, microangiopathy, type 2 diabetes