Abstract: Objective Evaluating the therapeutic effect and safety of the soothing liver and strengthening spleen method combined with western medicine on the treatment of peptic ulcer. Methods Searching CNKI, VIP, Wanfang, CBM, PubMed and other databases by computer and including literatures that meet the criteria. Meta-analysis was performed using Review Manager 5.4 software. Outcome indicators included clinical effective rate, quality of ulcer healing, Hp eradication rate, serum inflammatory factor, adverse reactions and recurrence rate. Results A total of 17 literatures were included, with a total of 1837 patients. The results of meta-analysis showed that compared with western medicine alone, the combination of soothing the liver and strengthening the spleen can improve the clinical efficiency of peptic ulcer(OR=4.67,95%CI: 3.24-6.72,Z=8.27,P<0.00001), promote ulcer healing(OR=2.36, 95%CI: 1.13-4.92, P=0.02), improve Hp cure rate(OR=2.82, 95%CI: 1.37-5.83, P=0.005), reduce serum inflammatory factor levels and the adverse reaction is small, recurrence rate is low. Conclusion Compared with western medicine alone, the combination of soothing the liver and strengthening the spleen has better curative effect, less adverse reactions and lower recurrence rate. Due to the general quality of the literature included in the study, the effectiveness and safety need to be verified by well-designed high-quality clinical randomized controlled trial.

Key words: soothing liver and strengthening spleen, peptic ulcer, meta analysis