Abstract: Objective To study and analyze the effect of Shexiang Baoxin Pill combined with Western medicine on endothelial dependent vasodilation function and plasma NO in patients with coronary heart disease. Methods 80 patients with coronary heart disease who received treatment from March 2021 to March 2023 in Fufeng County People's Hospital were selected as the research subjects. They were randomly numbered, and patients numbered with the odd number were set as control group (n=40), who were treated with Western medicine, while patients numbered with the even number were set as observation group (n=40), who were treated with Shexiang Baoxin Pill combined with Western medicine. Observe and compare the effect of ,treatment, vascular endothelial diastolic function after treatment, changes in plasma NO concentration before and after treatment, and various indicators of angina pectoris after treatment between the two groups. Results The total effective rate was 85.00% (34/40) in observation group and 55.00% (18/40) in control group, and the total effective rate was higher in observation group than that in control group, with statistically significant difference (P<0.05). There were no statistically significant differences in the comparison of basal internal diameter and nitroglycerin content indicators between the two groups (P>0.05). The reactive congestion index of the observation group patients was better than that of the control group, and the difference was statistically significant (P<0.05). The difference in plasma NO concentration before treatment between the two groups was not statistically significant (P> 0.05). After treatment, the plasma NO concentration levels of both groups of patients decreased, and the difference in plasma NO concentration between the observation group and the control group after treatment was statistically significant (P<0.05). There were no statistically significant differences in the number of attack of angina pectoris, duration, and visual analog score (VAS) between the two groups of patients before treatment (P>0.05). After treatment, the above indices were reduced in both groups and were lower in the observation group than in the control group, and the differences were statistically significant (P< 0.05). Conclusion The combined treatment of Shexiang Baoxin Pill and Western medicine has a significantly better therapeutic effect on patients with coronary heart disease than single Western medicine treatment. It can promote the recovery of reactive congestion index, improve endothelial dependent diastolic function, plasma NO levels, and correct electrocardiogram abnormalities.

Key words: Shexiang Baoxin pills, coronary heart disease, endothelial dependent vasodilation, plasma NO