Abstract: Objective To analyze the correlation and prognostic value of cyclin E, p53, CD44s, CD44v6 proteins in tumor tissues with early breast cancer. Methods From July 2018 to July 2020, 80 cases of early breast cancer patients with clinical stage Ⅰ-Ⅱ in our hospital were selected as the research object, and they were divided into malignant group, and another 80 cases of benign breast cancer patients treated in our hospital in the same period were selected as benign group. The expressions of cyclin E, p53, CD44s, CD44v6 in tumor tissues of the two groups were detected by immunohistochemistry, and the positive rates of the above indicators were compared. The correlation between cyclin E, p53, CD44s, CD44v6 and early breast cancer was analyzed by Spearman correlation analysis. All patients were treated with surgery, and then 80 patients with early breast cancer were followed up for 3 years. According to the follow-up results, the patients were divided into two subgroups, namely, the poor prognosis group (n=25) and the good prognosis group (n=55). The general clinical characteristics and the positive rates of cyclin E, p53, CD44s and CD44v6 in the two groups were compared, and the predictive value of cyclin E, p53, CD44s and CD44v6 for the prognosis of early breast cancer was analyzed by Logistic regression analysis. Results The positive rates of cyclin E, p53, CD44s and CD44v6 in malignant group were 42.50%, 61.25%, 77.50% and 81.25% respectively, which were significantly higher than those in benign group (1.25%, 5.00%, 10.00% and 12.50%, P<0.05); Spearman correlation analysis showed that cyclin E, p53, CD44s, CD44v6 were positively correlated with early breast cancer (P<0.05); There was no statistically significant difference in menopause, age, pathological type, tumor size and histological differentiation between the good prognosis group and the poor prognosis group (P>0.05). There was statistically significant difference in clinical stage, cyclin E, p53, CD44s, CD44v6 positive number between the good prognosis group and the poor prognosis group (P<0.05); The final Logistic regression analysis showed that the positive expression of cyclin E, p53, CD44s and CD44v6 were the independent factors influencing the prognosis of early breast cancer (P<0.05). Conclusion The expression levels of cyclin E, p53, CD44s and CD44v6 are significantly related to the occurrence and development of breast cancer, and the positive expression of these indicators is an independent predictor of poor prognosis in early breast cancer.

Key words: early breast cancer, cyclin E, p53, CD44s, CD44v6, immunohistochemistry