ZHONGHUA YANGSHENG BAOJIAN ›› 2024, Vol. 42 ›› Issue (19): 4-8.

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Multiple Regression Model of IRF9, PSMA5 Combined with M1/M2 Polarization Status of Peripheral Blood Macrophages to Predict Rheumatoid Arthritis Progression

GUAN Yue1, LI Xin1, YANG He-min2, XU Si-yu3, SHI Li-dong1, LIU Yang-yang1, KONG Ling-dan1, QIN Ying1,*   

  1. 1. Department of rheumatology and immunology, the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar Heilongjiang, 161006, China;
    2. Central Laboratory, the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar Heilongjiang, 161006, China;
    3. Inspection Center, the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar Heilongjiang, 161006, China
  • Online:2024-10-01 Published:2024-09-25

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Abstract: Objective To study the predictive value of IRF9 and PSMA5 combined with M1 and M2 macrophage polarization on rheumatoid arthritis (RA) progression. Methods A total of 87 RA patients were divided into active and remission groups based on disease severity. IRF9 and PSMA5 expression, M1 and M2 macrophage proportions, and the M1/M2 ratio were compared. Logistic regression and ROC analysis were used to assess predictive performance. Results Higher expression of IRF9 and PSMA5 was seen in active RA patients. M1/M2 ratio was higher in active RA. Logistic regression identified IRF9, PSMA5, and M1/M2 ratio as RA progression risk factors. AUC values for predicting RA progression were 0.690 for M1/M2, 0.664 for IRF9, and 0.733 for PSMA5. Conclusion M1/M2 polarization, IRF9, and PSMA5 levels were elevated in RA patients and correlated with disease progression. These markers could be valuable for assessing and evaluating RA progression clinically.

Key words: rheumatoid arthritis, macrophage, interferon regulatory factor 9, proteasome a5 subunit

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