Abstract: Objective To investigate the effect of Xiaoyukang capsule combined with Urinary Kallidinogenase in the treatment of acute cerebral infarction. Methods A retrospective analysis was conducted on the clinical data of 92 patients with acute cerebral infarction admitted to the People's Hospital of Dali Bai Autonomous Prefecture from January 2019 to January 2023. They were divided into two groups according to different intervention methods. The control group used Urinary Kallidinogenase, while the observation group was treated with Xiaoyukang capsules in combination with the control group.The effective rates of two treatment groups were calculated, critical pressure (CP), pulse wave number (Wv), minimum blood flow (Qmin), dynamic impedance (DR), peripheral resistance of cerebral vessels (R) and minimum blood flow velocity of carotid arteries (Vmin) were measured in the two groups, and serum levels of growth differentiation factor 15 (GDF-15), CXC chemokine 16 (CXCL-16), pentameric protein 3 (PTX3) and Monocyte chemotactic protein 1 (MCP-1) were measured. Results The effective rate of the observation group was significantly higher than control group (P<0.05). Before treatment, there was no significant difference in CP, Wv, Qmin, DR, R, and Vmin between the two groups (P>0.05). After treatment, the CP, Wv, Qmin, DR, R, and Vmin of the two groups were significantly improved (P<0.05), and the CP, Wv, Qmin, DR, R, and Vmin of the observation group were significantly better than those of the control group (P<0.05). Before treatment, there was no significant difference in serum levels of GDF-15, CXCL-16, PTX3, and MCP-1 between the two groups (P>0.05). After treatment, the serum levels of GDF-15, CXCL-16, PTX3, and MCP-1 in both groups were significantly reduced (P<0.05), and the serum levels of GDF-15, CXCL-16, PTX3, and MCP-1 in the observation group were significantly lower than those in the control group (P<0.05). Before treatment, there was no statistically significant difference in Barthal index between the two groups (P>0.05). After treatment, the Barthal index scores of the two groups significantly increased (P<0.05), and the observation group was higher than the control group (P<0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P<0.05). Conclusion The combination of Xiaoyukang Capsules and Urinary Kallidinogenase can significantly improve the therapeutic effect of acute cerebral infarction, improve cerebral hemodynamics, reduce inflammatory reactions, improve patients'daily living ability, and have high safety.

Key words: Xiaoyukang Capsules, yuriklin, acute cerebral infarction, hemodynamics, inflammatory factors