Abstract: Objective To explore the application value of Holter monitor combined with heart rate variability parameters in the diagnosis of ECG ST-T changes. Methods Chose 170 individuals who underwent physical examinations at Shaanxi Forest Industry Employee Hospital from July 2020 to April 2023 were selected as the research subjects. All enrolled individuals underwent electrocardiogram examinations, and were divided into the study group (n=85, with electrocardiogram ST-T changes) and the control group (n=85, without electrocardiogram ST-T changes) based on their test results. Dynamic electrocardiogram tests were performed on both groups of individuals, Record the percentage of quantitative parameters with a difference between adjacent NN intervals>50 ms in heart rate variability (PNN50), the root mean square (RMSSD) of the difference between adjacent NN intervals, and the standard deviation (SDNN) of all sinus rhythm RR intervals for comparison. Calculate the diagnostic value of dynamic electrocardiogram, quantitative parameters of heart rate variability, and combined detection for electrocardiogram ST-T by plotting ROC curves. Results The supraventricular premature beats and supraventricular tachycardia in Holter monitor of patients in the study group were significantly higher than those in the control group (P<0.05). The AUC of Holter monitor index for diagnosis of ST-T changes in electrocardiogram was 0.873 and 0.856, the consistency of the prompt data is good. The SDNN, RMSSD, and PNN50 of heart rate variability parameters in the study group were significantly higher than those in the control group (P<0.05). The diagnostic AUC of heart rate variability parameters SDNN, RMSSD, and PNN50 for ST-T changes in electrocardiogram were 0.845,0.622 and 0.799, suggesting that SDNN and PNN 50 showed good agreement in the diagnosis of ECG ST-T changes, while RMSSD had low agreement.By using a series connection method, the diagnostic consistency, sensitivity,and specificity of the combination of dynamic electrocardiogram and heart rate variability parameters for ST-T changes in electrocardiogram were 95.88%,98.82% and 92.94%. Conclusion The Holter monitor parameters and heart rate variability parameters of patients with ECG ST-T changes will change significantly. The application of the above quantitative parameters in the diagnosis of ECG ST-T changes has good clinical efficacy, and has a certain value of popularization and application.

Key words: holter monitor, heart rate variability parameters, changes in electrocardiogram ST-T, diagnostic effectiveness