Effect of Anlotinib Targeted Therapy on Immune Function and CYFRA21-1 and CEA in Patients With Non-small Cell Lung Cancer

Abstract

Abstract: Objective To investigate and analysis the effects of anlotinib targeted therapy on immune function and CYFRA21-1 and CEA in patients with non-small cell lung cancer. Methods From January 2019 to June 2020, a total of 87 cases of patients with non-small cell lung cancer who were diagnosed and treated in the Cancer Hospital Affiliated to Shantou University School of Medicine were selected as the research subjects. The patients were divided into anlotinib group of 44 cases and control group group of 43 cases according to the treatment methods. The control group were given radiotherapy, and the anlotinib group were given anlotinib based on the treatment of the control group. Both groups were treated for 4 weeks, and the immune function and the changes of CYFRA21-1 and CEA expression were detected. Results After treatment, the total effective rate of the anlotinib group was significantly higher than that of the control group, and the difference were statistically significant (P<0.05). The incidence rates of radiation pneumonitis and radiation esophagitis during radiotherapy in the anlotinib group was slightly lower than the control group, and the comparison was not statistically significant (P>0.05). The proportion of CD3⁺T lymphocytes and CD4⁺T lymphocytes in the anlotinib group after treatment were significantly higher than those before treatment (P<0.05), and the proportions of the two T lymphocytes of the anlotinib group were also significantly higher than those in the control group, and the differences were statistically significant (P<0.05). The serum CYFRA21-1 and CEA levels in the anlotinib group after treatment were significantly lower than those before treatment (P<0.05), and the levels of serum CYFRA21-1 and CEA in anlotinib group were also significantly lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion The application of anlotinib targeted therapy combined with radiotherapy in patients with non-small cell lung cancer can effectively inhibit the expression of serum CYFRA21-1 and CEA, improve the immune function of patients, effectively improve the treatment effect.

Key words: anlotinib, targeted therapy, radiotherapy, non-small cell lung cancer, immune function

CLC Number:

R734.2

GUO Dainian, FANG Ling, XU Jun, LIN Fei. Effect of Anlotinib Targeted Therapy on Immune Function and CYFRA21-1 and CEA in Patients With Non-small Cell Lung Cancer[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(9): 47-50.

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