The Relationship between Serum Levels of Adiponectin, Leptin and Irisin and Retinopathy in Male Patients with T2DM

Abstract

Abstract: Objective To investigate the association of three adipokines, serum adiponectin, leptin and irisin, with type 2 diabetic retinopathy (DR) in male and their diagnostic efficacy. Methods Total of 224 male patients with type 2 diabetes mellitus (T2DM) selected from the Affiliated Hospital of Qingdao University, from October 2020 to October 2021 were included and divided into observation and control groups according to the presence or absence of DR changes, and into non-value-added DR (NPDR) and value-added DR (PDR) subgroups according to the presence or absence of value-addedness, and serum lipocalin, leptin, irisin and clinically relevant data were tested and collected from the patients for relevant statistical analysis. Results There were significant differences between serum adiponectin, leptin and irisin in the observation group and the control group; the results of multifactorial Logistic regression analysis showed that serum irisin (OR=0.977,95% CI=0.964~0.994), leptin (OR=1.827, 95% CI=1.409~2.372), and adiponectin (OR=0.755, 95% CI=0.668~0.856) were risk factors for the development of DR; ROC curves showed that the combination of serum irisin, adiponectin and leptin had a high diagnostic value for DR (AUC=0.85) and PDR (AUC=0.82). Conclusion Serum adiponectin, leptin, and irisin are associated with the occurrence and extent of male DR, and are of value for the prevention and assessment of DR.

Key words: type 2 diabetes mellitus, diabetic retinopathy, adiponectin, leptin, irisin

CLC Number:

R587.2

NI Xun-qing, LIU Zi-shan, ZHENG Cui-juan, ZHANG Qing-hua, ZHANG Rui. The Relationship between Serum Levels of Adiponectin, Leptin and Irisin and Retinopathy in Male Patients with T2DM[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(23): 9-12.

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