Abstract: Objective To compare the effects of conventional surgery and minimally invasive surgery in the treatment of hyperthyroidism with thyroid cancer and its influence on thyroid function. Methods 80 patients with hyperthyroidism and thyroid cancer admitted to Longkou People's Hospital from January 2019 to January 2022 were selected and divided into two groups with 40 patients in each group. Patients in the control group were treated with conventional total thyroidectomy, and patients in the observation group were treated with radiofrequency ablation. The operation time, intraoperative blood loss, postoperative drainage, hospital length, treatment cost, tumor recurrence rate, and complication rate were compared with the expression level of inflammatory factors before and 1 d after surgery, and the thyroid function before and 15 d after surgery. Results In the observation group, the patients' operation time, intraoperative bleeding volume, postoperative discharge, hospitalization and complication rate of the were significantly lower than the control group (P<0.05); and CRP, TNF- α levels increased, lower than the control group (P<0.05), lower IL-2 levels, higher than the control group (P<0.05); TT3 and TT4 levels increased and higher than the control group, lower PTH level, and lower than the control group (P<0.05). Conclusion The recurrence rate of hyperthyroidism combined with thyroid cancer treated by conventional surgery and minimally invasive surgery is relatively low, but minimally invasive surgery can further reduce the damage to the surrounding thyroid tissue of patients, promote the early recovery of patients, reduce the incidence of complications, reduce the inflammatory reaction of patients, and improve the thyroid function of patients.

Key words: radiofrequency ablation, total thyroidectomy, hyperthyroidism, thyroid cancer, thyroid function