Abstract: Objective To analyze the effects of vacuum sealing drainage (VSD) combined with Nano silver dressing combination on the curative effect and inflammatory factors of chronic refractory wounds of diabetic foot. Methods 120 patients with diabetic foot of chronic refractory wounds patients admitted in The Third Hospital of Inner Mongolia Autonomous Region from January 2020 to August 2022 were selected, they were divided into two groups by random number table method: 57 cases in control group and 63 cases in observation group. All patients were treated with given anti-infection, blood glucose control and thorough wound debridement after admission, After debridement, only VSD was used to cover the wound in the control group, after debridement, Nano silver dressing was evenly applied on the wound in the observation group, and then VSD was used to cover the wound. When the wound in both groups reached the condition of skin graft, skin grafting was given. The wound healing rate, velocity of wound healing, wound edge reaction and exudation volume, inflammatory factors and curative effect index were compared between the two groups. Results The wound healing rate, velocity of wound healing, inflammatory factors and curative effect indexes of the observation group were significantly higher than those of the control group （P<0.05）, while the wound reaction and exudation volume of the observation group were significantly lower than those of the control group （P<0.05）. Conclusion VSD combined with Nano silver dressing can effectively promote the growth of granulation tissue, shorten the time of wound healing and improve the quality of wound healing, and effectively improve the survival rate of diabetic chronic refractory wound skin grafting.

Key words: vacuum sealing drainage, diabetic foot, wound healing, nano silver dressing