Abstract: Objective To understand the problems existing in the prevention of refeeding syndrome in critically ill patients and the application of intervention evidence, and to provide the basis for the formulation of corresponding action strategies. Methods Objective sampling method was adopted to conduct semi-structured interviews with doctors and nurses in intensive care units of a Grade-III Class A public hospital in Shanghai from October to December 2022. The interview data were sorted out, analyzed and extracted according to the Action Facilitation Framework for the application of research results in the field of health services (i-PARIHS framework). Results The interview content was summarized into three themes, included evidence of change: evidence application and environment did not match well; evidence application implementation is a dynamic process; change recipients: the knowledge reserve of practitioners needs to be improved, and the compliance of severe patients is poor; organizational environment: the workload increases in the early stage of reform, and it is urgent to improve the information system; lack of prescriptive documentation requiring changes in routine care practices. Conclusion Project implementation when carrying out the evidence application project, the evidence should be adjusted according to the suggestions of stakeholders, pay attention to the dynamic adjustment of treatment and nursing measures in the implementation process, timely update the evidence and actively carry out relevant training, do a good job of publicity and education to improve the compliance of critically ill patients, improve the information system for patient management, so as to ensure the continuity of evidence application.

Key words: critically ill patients, refeeding syndrome, i-PARIHS framework