Abstract: Objective To explore the application value of modified Yihuang Decoction combined with acupoint application in patients with HPV positive chronic cervicitis (CCS). Methods The clinical data of 74 patients with HPV-positive CCS admitted to Donggang District Maternal and Child Health Hospital of Rizhao City from September 2021 to September 2022 were analyzed retrospectively. They were divided into groups according to different treatment methods, among which 37 patients who received routine treatment were the control group, and 37 patients who received modified Yihuang Decoction combined acupoint application treatment were the observation group. Both groups were treated for 4 weeks. Compare and analyze the negative conversion of HPV, inflammatory reaction, immune function, TCM syndrome score and adverse reactions between the two groups. Results The negative rate of HPV in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05), After treatment, in the observation group, hypersensitive C-reactive protein (hs-CRP), interleukin (IL)-10, IL-6, IL-2, tumor necrosis factor-α(TNF-α) and the scores of excessive underband volume, abnormal underband color, low back pain and bloating, bitter mouth and dry throat, and frequent urination pain were lower than those of the control group, and the scores of CD4⁺, CD8⁺, CD4⁺/CD8⁺were higher than those of the control group, with statistically significant differences (P<0.05); There were no adverse reactions in both groups. Conclusion Modified Yihuang Decoction combined with acupoint application can promote HPV negative in HPV-positive CCS patients, reduce inflammatory reaction, improve immunity, and accelerate symptom recovery, with high safety.

Key words: chronic cervicitis, human papillomavirus, modified Yihuang Decoction, acupoint application, inflammatory response, immune function