Effect of Neovasin on Endothelium - Dependent Vasodilation and Plasma NO Level in Patients with Coronary Heart Disease undergoing Percutaneous Coronary Intervention

Abstract

Abstract: Objective To investigate the effects of lyophilized recombinant human brain natriuretic peptide on endothelium dependent vasodilation and plasma NO in patients with coronary artery disease (CAD) after percutaneous coronary intervention. Methods From March 2020 to March 2022, 100 patients with coronary intervention who were admitted to the Hongqi Hospital affiliated to Mudanjiang Medical College were selected and divided into two groups (named study group and control group respectively) according to the random number table. The patients were treated with routine drugs (according to the clinical manifestations and characteristics of the disease, the patients were given a reasonable treatment plan, including nitrates, antiplatelet drugs, anticoagulants, etc.). The study group of 50 patients was treated with lyophilized recombinant human brain natriuretic peptide on a routine basis. The clinical efficacy, changes in biochemical indicators, flow mediated dilation (FMD) Plasma (nitric oxide, NO) and the incidence of adverse reactions. Results The total effective rate of patients in the study group was significantly higher than that in the control group (P<0.05). There was no significant difference in hs-CRP, BNP and IL-6 between the two groups before treatment (P>0.05), after treatment, the indexes in the study group were significantly lower than those in the control group (P<0.05). There was no significant difference between the two groups in the levels of FMD and plasma NO before treatment (P>0.05), and after treatment, the levels of FMD and plasma NO in the two groups were both increased (P<0.05), and the levels of the above indicators in the study group were higher than those in the control group (P<0.05). The incidence of adverse reaction in the study group was lower than that in the control group (P<0.05). Conclusion Lyophilized recombinant human brain natriuretic peptide can improve endothelium dependent vasodilation function, improve cardiac function, increase plasma NO content in patients with coronary heart disease after intervention. It has significant effect, and the incidence of adverse reactions is low. Furthermore, it is safe and reliable. It provides a new idea and treatment method for the treatment of coronary heart disease.

Key words: lyophilized recombinant human brain natriuretic peptide, coronary heart disease, endothelium-dependent vasodilation, plasma NO

CLC Number:

R543

XIE Jun, FU Bei-jing, GAO Feng-min. Effect of Neovasin on Endothelium - Dependent Vasodilation and Plasma NO Level in Patients with Coronary Heart Disease undergoing Percutaneous Coronary Intervention[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(24): 8-11.

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