Therapeutic Effect of Lupatadine Fumarate Combined with Yupingfeng Granule on Chronic Urticaria

Abstract

Abstract: Objective To investigate the effect oflupatadine fumarate combined with Yupingfeng Granule on chronic urticaria. Methods A total of 104 patients with chronic urticaria who were treated in the Second Affiliated Hospital of Guilin Medical College from January 2021 to December 2021 were selected and divided into two groups by random number table method, with 40 patients in each group.The control group received lupatadine fumarate tablets, while the observation group received lupatadine fumarate tablets and Yupingfeng granules.The treatment effective rate and recurrence rate of the two groups were observed, and the serum interleukin (IL)-4, immunoglobulin E (IgE), IL-8, interferon-γ (INF-γ) and IL-17 levels, and assess for changes in symptoms. Results The effective rate of the observation group wassignificantly higher than control group (P<; 0.05), and the recurrence rate was lower than control group (P<; 0.05). After treatment, the levels of serum IL-4, IgE, IL-8 and IL-17 in the two groups were significantly decreased (P<; 0.05), the level of INF-γ was increased (P<; 0.05). And the levels of serum IL-4, IgE, IL-8 and IL-17 in the observation group were significantly lower than thosein the control group (P<; 0.05), the levels of serum INF-γ were significantly higher than those in the control group (P<; 0.05). Before treatment, there were no significant differences in the number of wheals, itching degree, duration of wheals, the largest diameter of wheals and the number of daily wheals attacks between the two groups (P>; 0.05). After treatment, the number of wheals, itching degree, duration of wheals, the largest diameter of wheals and the number of daily wheals attacks were significantly reduced between the two group (P<; 0.05). And the number of wheals, itching degree, duration of wheals, the largest diameter of wheals and the number of daily wheals attacks in the observation group were significantly reduced (P<; 0.05). Conclusion Lupatadine fumarate combined with Yupingfeng granule has significant curative effect on chronic urticaria, which is worth popularizing.

Key words: rupatadine fumarate, Yupingfeng Granules, chronic urticaria

CLC Number:

R758.24

WANG Fu-dong, LIU Jia, JIANG Shu-ling. Therapeutic Effect of Lupatadine Fumarate Combined with Yupingfeng Granule on Chronic Urticaria[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(24): 5-8.

References

[1] 叶峻宏,韩宪伟,吕雯,等.金蝉止痒胶囊联合依匹斯汀治疗慢性荨麻疹临床疗效及对血清炎性因子的影响[J].湖北中医药大学学报,2021,23(3):81-83.
[2] 郑子恢,张碧华,李琼,等.复方甘草酸苷联合左西替利嗪治疗慢性荨麻疹有效性和安全性的Meta分析[J].临床药物治疗杂志,2022,20(2): 60-66.
[3] 陈耿明,王锦云,黄亿平.玉屏风颗粒及枸地氯雷他定联合粉尘螨滴剂治疗慢性自发性荨麻疹的疗效[J].中国医师杂志,2021,23(8): 1243-1246.
[4] 中华医学会皮肤性病学分会荨麻疹研究中心.中国荨麻疹诊疗指南(2018版)[J].中华皮肤科杂志,2019,52(1):1-5.
[5] 陈达灿,范瑞强.皮肤性病科专病中医临床诊治(第3版)[M].北京:人民卫生出版社,2013:114-116.
[6] 孙田,王珺,王东.当归四逆加吴萸生姜汤加味联合枸地氯雷他定片治疗慢性荨麻疹的临床观察[J].世界中医药,2020,15(2):256-260.
[7] 王栩芮,傅文斌,孙弋淇,等.当归饮子联合西替利嗪治疗慢性荨麻疹患者的疗效及对免疫炎症因子的影响[J].中国中西医结合杂志,2021,41(7):877-880.
[8] 张丛敏,朱晓静,魏金铠,等.玉屏风颗粒联合脾氨肽口服冻干粉治疗小儿肺炎的疗效及对细胞因子和免疫功能的影响[J].中国医师杂志,2021,23(9):1395-1398.
[9] 齐海花,黄占强,何磊,等.玉屏风颗粒对过敏性紫癜患者外周血Th1/Th2型细胞因子的影响及预防复发作用[J].中国中西医结合皮肤性病学杂志,2020,19(3):241-243.
[10] 刘婷,杨雪,颜红炜.卡介菌多糖核酸联合玉屏风颗粒治疗慢性荨麻疹的疗效及机制分析[J].安徽医药,2018,22(4):735-738.
[11] 杨丽丽,谷力彬,武文印,等.加减秦艽牛蒡汤治疗湿热蕴肤型慢性荨麻疹及对血清IL-4,IgE和IFN-γ的影响[J].天津中医药大学学报,2019,38(3):251-254.
[12] 殷董,孙晓燕,王星武,等.特异性免疫疗法治疗慢性荨麻疹患者的疗效及对血清IgE,IL-4,IFN-γ和生活质量的影响[J].现代生物医学进展,2018,18(18):3494-3497.
[13] 赵军,李燕,胡新华.刺络拔罐配合自血穴位注射对慢性荨麻疹患者血清IL-4、IFN-γ水平及安全性的影响研究[J].针灸临床杂志,2018,34(10):14-17.
[14] 刘丽娟,赵瑞芝,卢传坚.固本抗敏方对脾肾阳虚型慢性荨麻疹模型大鼠血清IgE,IFN-γ及腹腔液肥大细胞脱颗粒的影响[J].中医杂志,2021,62(2):163-168.
[15] 随永敏. 引气归元方联合依匹斯汀、脾氨肽治疗慢性荨麻疹的疗效及对血清IL-4、IFN-γ的影响[J].现代中西医结合杂志,2018, 27(24):2690-2693.
[16] 周培媚,付丽新,陈涛,等.慢性自发性荨麻疹血清IL-17的表达及其与病情的相关性研究[J].中国中西医结合皮肤性病学杂志,2019, 18(4):299-301.
[17] 郭志远,李浩飞,兰红斌.血府逐瘀汤并西替利嗪片对血瘀型荨麻疹患者血清中细胞因子及T淋巴细胞水平的影响[J].精准医学杂志,2019,34(4):311-314.
[18] 刘凤英,胡建锋,蒋彬.慢性荨麻疹患者T细胞亚群、白细胞介素、免疫球蛋白与补体的检测及临床意义[J].中国卫生检验杂志,2018, 28(1):76-78.