Abstract: Objective To investigate the clinical efficacy of dyclonine hydrochloride mucilage combined with flurbiprofen axetil in the prevention of catheter-induced bladder irritation symptoms in men after general anesthesia endoscopic lithotripsy. Methods A total of 80 male patients with upper urinary tract stones admitted to our urology department from January 2020 to December 2021 were selected and divided into four groups using the randomized numerical table method. Group A was the dyclonine hydrochloride mucilage group. Group B was the flurbiprofen axetil group. Group C was the dyclonine hydrochloride mucilage combined with flurbiprofen Axetil group, and group D was the control group, with 20 cases in each group. After lithotripsy, before catheterization, groups A and C injected 3 mL of dyclonine hydrochloride mucilage into the urethra and used dyclonine hydrochloride mucilage to lubricate the catheter for catheterization, while groups B and D used aqueous lubricant to lubricate the catheter for catheterization. Following return to the ward, groups B and C were immediately given 0.9% NaCl solution 100 mL + flurbiprofen axetil 50 mg IV, and groups A and D were given 0.9% NaCl solution 100 mL IV. The period between the removal of the laryngeal mask for general anesthesia awakening and the removal of the urinary catheter was divided into three time periods. The time period from mask removal to ward return was T1, the time period from ward return to full wakefulness was T2, and the time period from full wakefulness to urethral catheter removal was T3. The occurrence of catheterization-related agitation at different stages was observed in each group, and the pain level at different time periods was evaluated using the pain numerical rating scale (NRS). Results The agitation rate of group C at T1 time was lower than that of B and D groups (P<0.05), and there was no statistical difference compared with group A (P>0.05); the agitation rate of group C at T2 time was lower than that of groups A and D (P<0.05), there was no statistical difference compared with group B (P>0.05); there was no statistical difference in the incidence of urinary catheter agitation among the four groups at T3 time (P>0.05). At the same time, with the extension of time, the restlessness rate of each group gradually decreased (P<0.05). The NRS score of group C at T1 time was lower than that of B and D groups (P<0.05), and there was no statistical difference compared with group A (P>0.05); the NRS score of group C at T2 time The score was lower than that of group A and D (P<0.05), and had no statistical difference compared with group B (P>0.05); the NRS score of group C at T3 time was lower than that of group A (P<0.05), and there was no statistical difference compared with group B and D (P>0.05); at the same time, with the prolongation of time, the NRS scores of groups B and C gradually decreased (P<0.05). Conclusion sThe combination of dyclonine hydrochloride mucilage with flurbiprofen axetil in men after general anesthesia endoscopic can significantly and consistently reduce the symptoms of bladder irritation caused by catheter and relieve pain, and the effect is better than that of single drug use, which is worthy of clinical promotion.

Key words: dyclonine hydrochloride mucilage, flurbiprofen axetil, catheter-related bladder discomfort