Abstract: Objective To investigate and compare the efficacy and safety of ibutilide and amiodarone in the treatment of new-onset atrial fibrillation after permanent cardiac pacemaker implantation. Methods From January 2019 to March 2022, A total of 88 patients with new-onset atrial fibrillation after permanent cardiac pacemaker implantation who were diagnosed and treated in our hospital from were selected as the research subjects, and the patients were divided into the control group and the combined group accorded to the simple allocation principle with 44 cases in each group. The control group was given amiodarone treatment, and the combined group was given ibutilide treatment on the basis of the treatment of the control group. The two groups were treated for 7 days. The conversion rate and conversion time within 1 hour of treatment, the changes of QT interval and Tpeak-end/QT interval before and after treatment, the total effective rate at 7 days after treatment, the recurrence rate of atrial fibrillation within 7 days after treatment and the occurrence of adverse reactions at 7 days after treatment were compared between the two groups. Results Compared with the control group, the combined group had higher cardioversion rate and shorter cardioversion time, and the differences were statistically significant(P<0.05). There was no significant difference in the QT interval and Tpeak-end/QT interval between the two groups before treatment (P>0.05).After treatment, there was no significant difference in QT interval and Tpeak-end/QT interval at 2 h in the combination group compared with before treatment (P>0.05), but the QT interval and TPEak-END /QT interval of the control group were significantly different before and after treatment (P<0.05), and the above indexes of the combined group were significantly lower than those of the control group after treatment (P<0.05). After 7 days of treatment, the total effective rate of the combined group was 97.73%, which was significantly higher than 84.09% of the control group,but there was no significant difference (P > 0.05). After treatment for 7 d, the recurrence rate of AF in the combined group was 4.54%, and that in the control group was 2.27%, and there was no significant difference between the two groups (P>0.05).The incidence rates of transient sinus block, hypotension, sinus bradycardia, atrioventricular block and other adverse reactions in the combined group 7 days after treatment was 4.54%, which was significantly lower than 22.73% in the control group (P<0.05). Conclusion The application of ibutilide combined with amiodarone in the treatment of new-onset atrial fibrillation after permanent pacemaker implantation can improve the conversion rate and speed up the conversion time, the recurrence rate of postoperative atrial fibrillation is low and the adverse reactions are controllable, which is worthy of clinical application.

Key words: ibutilide, amiodarone, permanent pacemaker implantation, atrial fibrillation, conversion rate, electrocardiogram, adverse reactions