Abstract: Objective To investigate the effect of Yishen Mingmu Recipe combined with Xueshuantong for injection on the quality of life and serum Endothelin-1 level in patients with glaucoma. Methods FA total of 60 glaucoma patients who were diagnosed and treated in the Department of Ophthalmology, Changshu Hospital Affiliated to Nanjing University of Traditional Chinese Medicine from August 2018 to December 2021 were retrospectively selected as the research subjects. According to the treatment methods, the patients were divided into the control group and the treatment group with 30 cases each group. The patients in the control group was treated with Xueshuantong for injection, and the treatment group was treated with Yishen Mingmu Recipe on the basis of the control group. Both groups were treated and observed for 3 months, total effective rate of best corrected vision, intraocular pressure, changes in anterior chamber depth, complications,the quality of life and serum Endothelin-1 status were observed and recorded. Results The total effective rate of the best corrected visual acuity in the treatment group after treatment was 96.67%, which was higher than that in the control group, which was 83.33%, but there was no significant difference between the groups (P>0.05). The intraocular pressure of the treatment group and the control group after treatment was significantly lower than that before treatment (P<0.05), and the depth of the central anterior chamber was significantly higher than that before treatment (P<0.05). After treatment, the intraocular pressure of the treatment group was lower than that of the control group (P<0.05), and the depth of the central anterior chamber was higher than that of the control group (P<0.05). The incidence rates of corneal epithelial edema, anterior chamber exudation, hyphema during treatment in the treatment group was 3.33%, which was significantly lower than that in the control group (26.67%),(P<0.05). The serum ET-1 content in the treatment group and the control group after treatment was significantly lower than that before treatment (P<0.05), and the treatment group was also significantly lower than that in the control group (P<0.05). The scores of life satisfaction, mental health, emotional health and other quality of life in the treatment group after treatment were significantly higher than those in the control group (P<0.05). Conclusion The application of Yishen Mingmu Recipe combined with Xueshuantong for injection in patients with glaucoma has good safety, can reduce the occurrence of complications, promote the reduction of intraocular pressure, and improve the best corrected visual acuity and central anterior chamber depth of patients. It can also promote the reduction of serum Endothelin-1 content and improve the quality of life of patients.

Key words: Yishen Mingmu Recipe, Xueshuantong for injection, glaucoma, intraocular pressure, best corrected visual acuity, central anterior chamber depth, endothelin-1