Abstract: Objective To analyze the clinical effect of Wucao Qingquan Decoction combined with western medicine in the treatment of acute pyelonephritis. Methods A total of 100 patients with acute pyelonephritis who were treated in the nephrology department of Tai’an Traditional Chinese Medicine Hospital from December 2018 to December 2019 were selected and divided into the experimental group and the conventional group by random number table method, with 50 cases respectively. The conventional group was treated with western medicine, and the experimental group was treated with Wucao Qingquan Decoction on the basis of the conventional group. The clinical treatment efficiency, the changes of urea nitrogen, serum creatinine and 24-hour urinary protein before and after treatment in the two groups were compared and analyzed. Results The total effective rate of the experimental group was higher than that of the conventional group, with homogeneity between groups（P<0.05）. Before treatment, there was no difference in the changes of urea nitrogen, serum creatinine and 24-hour urinary protein between the two groups（P>0.05）; after treatment, the urea nitrogen, serum creatinine and 24-hour urinary protein of the experimental group were lower than those of the conventional group, with significant difference（P<0.05）. Conclusion For acute pyelonephritis, Wucao Qingquan Decoction combined with western medicine can relieve clinical symptoms, and the clinical effect is significant.

Key words: Wucao Qingquan Decoction, Western medicine, Acute pyelonephritis, Clinical effect