Abstract: Objective To explore and study the significance of acute respiratory distress syndrome (ARDS) severity in the prognosis assessment of multiple organ failure. Methods From May 2019 to May 2021, 110 patients with multiple organ failure were selected in the department of critical care medicine of Xuzhou hospital of traditional Chinese medicine, Emergency Intensive Care Unit(EICU)were selected as the research object, the severity of ARDS in all patients were determined, and the prognosis of the patients were investigated and given correlation analysis. Results All patients were followed up until February 2022, with no loss of cases and 20 deaths, and the mortality rate was 18.18 %. The age and mechanical ventilation time of the death group were significantly higher than those of the survival group, and the difference was statistically significant (P<0.05). The incidence of ARDS in the death group were higher than that in the survival group, and the acute physiology and chronic health evaluation (APACHE II) and clinical pulmonary infection score (CPIS) scores were higher than those in the survival group that compared were statistical significance (P<0.05). Spearman and Pearson correlation analysis showed that the prognosis of deathwere correlated to the ARDS, APACHE II score, CPIS score, age, mechanical ventilation time(P<0.05). Multivariate logistic regression showed that ARDS, APACHE II score, CPIS score, age, and mechanical ventilation time were the main factors leaded to death (P<0.05). Receiver operator characteristic curve (ROC) analysis showed that ARDS evaluated the area under curve (AUC) value of multi-organ failure prognosis and death were 0.918. Conclusion Multiple organ failures are often accompanied by ARDS, which can lead to poor prognosis. ARDS, APACHE II score, CPIS score, age, and mechanical ventilation time are the main factors leading to the death of patients.

Key words: acute respiratory distress syndrome, multiple organ failure, prognosis, acute physiology and chronic health score, clinical pulmonary infection score, receiver operator characteristic curve