Prognostic Value of Serum sST2 and hs-CRP in the Occurrence, Success and Recurrence of NVAF

Abstract

Abstract: Objective To investigate the predictive value of serum soluble growth-stimulated expressed gene 2 protein (sST2) and highly sensitive C-reactive protein (hs-CRP) in the occurrence, success and recurrence of nonvalvular atrial fibrillation (NVAF). Methods 1 000 patients with coronary heart disease, hypertension and heart failure admitted to the Second Affiliated Hospital of Qiqihar Medical College from 2021 to 2024 were retrospectively selected and grouped according to whether they were combined with nonvalvular atrial fibrillation. Patients receiving cardioversion therapy were further grouped and analyzed to collect sST2, hs-CRP and related clinical indicators. Results sST2, hs-CRP and left anteroposterior atrial diameter(LAD) in patients with coronary heart disease and AF were higher than those without AF, the difference was statistically significant (P<0.05). sST2, hs-CRP and LAD in hypertensive patients with nonvalvular atrial fibrillation were higher than those in hypertensive patients without nonvalvular atrial fibrillation, and the difference was statistically significant (P<0.05). sST2, hs-CRP and LAD in patients with heart failure and nonvalvular atrial fibrillation were higher than those without heart failure and the difference was statistically significant (P<0.05). The level of sST2 in patients with successful total recovery of different diseases was lower than that of patients without successful total recovery of different diseases, and the difference was statistically significant (P<0.05). The hs-CRP level of patients with different disease types with successful total recovery was lower than that of patients with different disease types without successful total recovery, and the difference was statistically significant (P<0.05). The level of sST2 in the relapse group of different diseases was higher than that in the non-relapse group of different diseases, and the difference was statistically significant (P<0.05). The level of hs-CRP in the relapsed group was higher than that in the non-relapsed group, and the difference was statistically significant (P<0.05). Conclusions ST2 may reflect myocardial fibrosis, while hs-CRP may indicate inflammation, which jointly affect the occurrence and outcome of nonvalvular atrial fibrillation. Monitoring sST2 and hs-CRP levels is helpful to evaluate the condition, guide individualized treatment, and provide biomarker basis for accurate diagnosis and treatment of nonvalvular atrial fibrillation.

Key words: nonvalvular atrial fibrillation, soluble growth-stimulated expressed gene 2 protein, highly sensitive C-reactive protein, myocardial fibrosis, inflammatory marker

CLC Number:

R540.4

ZHANG Xin-rui, ZONG Hao, HAN Dong-xue, HAN Wen-xue, LI Yi-tong, CAI Yu, WANG Yi-cong, ZHANG Lin, WANG Yan-li. Prognostic Value of Serum sST2 and hs-CRP in the Occurrence, Success and Recurrence of NVAF[J]. ZHONGHUA YANGSHENG BAOJIAN, 2025, 43(12): 1-6.

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