Abstract: Objective To observe the clinical effect of laparoscopic radical resection of colon cancer in patients with colon cancer. Methods 74 patients with colorectal cancer treated in Zhangye Second People's Hospital from April 2021 to November 2023 were selected and divided into control group and observation group with 37 cases in each group by random number table method. The control group received conventional open surgery, and the observation group received laparoscopic radical resection of colon cancer. Serological indexes, perioperative related indexes, stress response and complications were compared between the two groups. Results Before operation, there was no difference in the levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 125 (CA125) between two groups (P>0.05). After operation, serum CEA and CA125 levels in 2 groups were lower than before operation, and observation group was lower than control group, the difference was statistically significant (P<0.05). The intraoperative blood loss and postoperative drainage volume in the observation group were lower than those in the control group, and the operation time, postoperative exhaust time, bowel sound recovery time, diet recovery time and hospital stay in the observation group were shorter than those in the control group, with statistical significance (P<0.05). Before operation, there was no difference in serum epinephrine, norepinephrine and cortisol levels between the two groups (P>0.05). After operation, the serum levels of epinephrine, norepinephrine and cortisol in 2 groups were higher than before operation, but the observation group was lower than control group, the difference was statistically significant (P<0.05). The incidence of complications in the observation group was lower than control group, and the difference was statistically significant (P<0.05). Conclusion Laparoscopic radical resection of colon cancer is effective in the treatment of colon cancer patients, which can promote the recovery of patients, reduce the level of tumor markers, reduce the stress reaction of surgery, and reduce the risk of complications.

Key words: laparoscopic radical resection of colon cancer, colon cancer, carcinoembryonic antigen, carbohydrate antigen 125, stress response