Abstract: Objective To analyze the results of colorectal cancer primary screening of permanent residents in Baihedong Street, Liwan District, Guangzhou City, 2020-2022, and to explore the risk factors affecting colorectal cancer positivity, so as to provide a basis for clinical prevention and treatment of colorectal cancer. Methods A total of 1,131 residents participating in colorectal cancer screening in Baihedong Street, Liwan District, Guangzhou City, China, from 2020 to 2022 were selected as the study subjects, and a combination of questionnaires and fecal occult blood tests (FOBTs) was used to conduct the screening as well as correlation analyses of risk factors. Results The initial screening results of 181 residents were positive, with a positive rate of 16.01%, of which 88 (48.6%) were male, 93 (51.4%) were female; 946 residents were negative, with a rate of 83.64%; and 4 cases could not be determined, with a rate of 0.35%.The proportion of patients with a history of chronic constipation, mucous blood stools, chronic cholecystitis, intestinal polyps, chronic appendicitis, and a history of cancer in the group with positive initial screening results was higher than the proportion of patients in the group with negative initial screening results, and the difference was statistically significant (P<0.05).The results of multifactorial analysis revealed that a history of mucous blood stools, a history of intestinal polyps, and a positive FOBT remained risk factors for a positive primary screening result (P<0.05). Conclusion Preliminary colorectal cancer screening results of residents aged 45-74 years in Baihedong Street, Liwan District, Guangzhou City, China, indicate that a history of mucous bloody stools, a history of intestinal polyps, and FOBT positivity are the key risk factors for colorectal cancer,It is suggested that people with such risk factors should undergo more frequent screening and further investigations such as colonoscopy for early diagnosis and treatment and to reduce morbidity.

Key words: colorectal cancer, fecal occult blood test, survey questionnaire, screening, risk factors