Discussion on the Regularity and Mechanism of Flower Drugs in Treating Acne by Data Mining and Network Pharmacology

Abstract

Abstract: Objective To explore the rule of treating acne with flowers and the mechanism of high-frequency flowers by Liu Fuxing School in southern Yunnan. Methods Collect outpatient medical records and analyze the tropism of sex and taste, category efficacy and association rules; Screening high-frequency flowers and acne targets, and taking intersection genes; Traditional Chinese medicine-component-target network and PPI network were constructed, and GO and KEGG analysis were carried out to visualize the molecular docking results. Results Heat-clearing drugs were the main drugs, with 11 core drugs. High-frequency flower drugs are honeysuckle, chrysanthemum indicum, safflower and rose, which have 6 core components and 7 core targets, involving cancer, lipid, endocrine and other pathways, and have good molecular docking and binding ability. Conclusion Liu Fuxing School in southern Yunnan pays attention to the middle and upper energizer, harmonizing qi and blood, taking clearing away heat as the main method and five-flavored disinfectant as the basic prescription, and strives for both attack and tonic, balancing cold and heat, and nourishing yin and yang. Flower drugs may act on acne targets through MAPK pathway, immune-inflammatory reaction, lipid and endocrine, among which stigmasterol and β-sitosterol may be the main components.

Key words: flower medicine, acne, data mining, network pharmacology, molecular docking

CLC Number:

R275.9

ZHAO Yue, LIAO Cheng-cheng, ZHAO Wen-bin, GUO Yuan-yuan, GUO Qing, XIE Bing, CHENG Jie. Discussion on the Regularity and Mechanism of Flower Drugs in Treating Acne by Data Mining and Network Pharmacology[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(11): 70-74.

References

[1] HENG A H S, CHEW F T. Systematic review of the epidemiology of acne vulgaris[J]. Sci Rep,2020,10(1):5754.
[2] 王天怡,宋坪.浅谈中医治疗湿疹类疾病的流派特点[J].环球中医药,2015,8(1):69-71.
[3] 赵颖. 中医皮肤科学术流派研究[D].济南:山东中医药大学,2009.
[4] 欧阳晓勇. 当代中医皮肤科临床家丛书:刘复兴[M].第2辑.北京:中国中医药出版社,2015:194.
[5] 赵辨. 中国临床皮肤病学[M].南京:江苏科学技术出版社,2017:1288-1293.
[6] 欧阳晓勇. 刘复兴治疗皮肤病经验[J].中医杂志,1998,39(9):528-529.
[7] 刘复兴,秦国政.擅用虫药攻克皮肤疮疡顽症——刘复兴学术思想与临床经验集[M].北京:中国中医药出版社,2014:7.
[8] 陆国兰. 刘复兴主任医师治疗痤疮经验介绍[J].湖南中医药导报,1999,5(2):16-17.
[9] 范乙林,何聪,王晓素.基于“平正轻灵”浅析花类药调理脾胃枢机之妙用[J].环球中医药,2022,15(10):1643-1646.
[10] 姬壮壮,祁向争,于志强.于志强运用花类药调节肝之疏泄经验[J].西部中医药,2022,35(7):43-45.
[11] 张新荣,徐国梅,袁姣姣,等.中药及其提取物治疗痤疮的作用靶点探析[J].西部中医药,2023,36(11):157-161.
[12] 张美荣,刘举,王洋.丝裂原激活蛋白激酶相关疾病及其药物的研究进展[J].中国药物化学杂志,2014,24(3):231-240.
[13] LIAO P C, LAI M H, HSU K P, et al.Identification of β-Sitosterol as in Vitro Anti-Inflammatory Constituent in Moringa oleifera[J]. J Agric Food Chem,2018,66(41):10748-10759.
[14] 陈元堃,曾奥,罗振辉,等.β-谷甾醇药理作用研究进展[J].广东药科大学学报,2021,37(1):148-153.
[15] 周琼艳,林薇,许素玲,等.STAT在皮肤病发病中作用的研究进展[J].基础医学与临床,2021,41(8):1205-1209.
[16] ANTWI A O, OBIRI D D, OSAFO N, et al.Stigmasterol Alleviates Cutaneous Allergic Responses in Rodents[J]. Biomed Res Int,2018,2018:3984068.
[17] 汪帅,孙宇,李春梅,等.豆甾醇的研究进展概述[J].中国药业,2019,28(23):96-98.
[18] 汤红燕,肖斌,刘鑫,等.寻常痤疮发病机制相关信号通路的研究进展[J].中国医学科学院学报,2020,42(4):559-561.
[19] 冯馨锐,崔雨舒,何志涛,等.肿瘤坏死因子-α的生物学功能研究进展[J].吉林医药学院学报,2019,40(1):66-68.
[20] MELNIK B C. p53:key conductor of all anti-acne therapies[J]. J Transl Med,2017,15:195.