Abstract: Objective To explore and analysis the relationship between serum alkaline phosphatase expression and postoperative healing of osteoporotic spinal fractures in postmenopausal women. Methods The study period were from January 2018 to January 2022, and 76 cases of postmenopausal female patients with osteoporotic spinal fractures who were treated at a certain hospital were selected as the research subjects. The serum alkaline phosphatase expression levels of all patients were detected, and the fracture healing time of the patients were followed up for correlation analysis. Results All patients were completed balloon dilation and kyphoplasty of vertebral body,and there were no serious complications during the perioperative period. Followed up until May 1, 2023,the average fracture healing time of 76 patients were (67.28±1.38) days, with a minimum of 45 days and a maximum of 114 days. There were 16 cases of delayed fracture healing that accounted for 21.05%(delayed healing group). There were no significant difference in gender, body mass index, main site of fracture, and time from fracture to surgery compared between the delayed healing group and the normal healing group (P>0.05), but there were significant difference in bone density, age, diabetes compared between the two groups (P<0.05). There were no significant difference in surgical time and intraoperative bleeding compared between the two groups (P>0.05), while there were significant difference in diabetes and hospitalization time compared between the delayed healing group and the normal healing group (P<0.05). The serum alkaline phosphatase content in the delayed healing group were significantly higher than that in the normal healing group (P<0.05). In the 76 patients, Pearson analysis showed there were correlation between serum alkaline phosphatase content, diabetes, postoperative hospital stay, bone density, age, and fracture healing time (P<0.05). Multiple logistic regression analysis showed that serum alkaline phosphatase content, diabetes, postoperative hospitalization time, bone density,age,and other important factors affected the healing time of postmenopausal women with osteoporotic spinal fractures(P<0.05). Conclusion The incidence of osteoporotic spinal fracture healing in postmenopausal women is relatively high, which is correlated with the patient's serum alkaline phosphatase content,age, bone density,diabetes and postoperative recovery. Serum alkaline phosphatase content is an important factor affecting fracture healing time.

Key words: postmenopausal women, osteoporosis, spinal fractures, alkaline phosphatase, correlation, fracture healing time, delayed healing